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CTDSP2 (NM_005730) Human Untagged Clone

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SKU
SC324051
CTDSP2 (untagged)-Human CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 (CTDSP2)
  $300.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol CTDSP2
Synonyms OS4; PSR2; SCP2
Vector pCMV6-AC
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>OriGene sequence for NM_005730.3 GGAGCTGCCGCTGGGGGATCGGGGCCGGGGGCACCCGGGGGAGCCGCTGCCCGGGCCGCC
CGCCCTTTGTACAGGCCGCCTCCCTTCCCGGTCCGGGGAGGAAACGAGAGGGGGGATGTG
AACAGCTGTGGAAGTCGGAGTCTCGGGAGCCGGAGCGGGCCCCCGCCCAGGCCCCCCAGC
CCAGCCCAGCCCGCGCGCCCGCCCGTCCTCCCGCCCAGCCAGCCCGGGCCCGCGGGATTG
TTAGATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCAC
CAAGCAAGGCCTGGTCTCCAAGTCCTCTCCTAAGAAGCCTCGTGGACGTAACATCTTCAA
GGCCCTTTTCTGCTGTTTTCGCGCCCAGCATGTTGGCCAGTCAAGTTCCTCCACTGAGCT
CGCTGCGTATAAGGAGGAAGCAAACACCATTGCTAAGTCGGATCTGCTCCAGTGTCTCCA
GTACCAGTTCTACCAGATCCCAGGGACCTGCCTGCTCCCAGAGGTGACAGAGGAAGATCA
AGGAAGGATCTGTGTGGTCATTGACCTCGATGAAACCCTTGTGCATAGCTCCTTTAAGCC
AATCAACAATGCTGACTTCATAGTGCCTATAGAGATTGAGGGGACCACTCACCAGGTGTA
TGTGCTCAAGAGGCCTTATGTGGATGAGTTCCTGAGACGCATGGGGGAACTCTTTGAATG
TGTTCTCTTCACTGCCAGCCTGGCCAAGTATGCCGACCCTGTGACAGACCTGCTGGACCG
GTGTGGGGTGTTCCGGGCCCGCCTATTCCGTGAGTCTTGCGTGTTCCACCAGGGCTGCTA
CGTCAAGGACCTCAGCCGCCTGGGGAGGGACCTGAGAAAGACCCTCATCCTGGACAACTC
GCCTGCTTCTTACATATTCCACCCCGAGAATGCAGTGCCTGTGCAGTCCTGGTTTGATGA
CATGGCAGACACTGAGTTGCTGAACCTGATCCCAATCTTTGAGGAGCTGAGCGGAGCAGA
GGACGTCTACACCAGCCTTGGGCAGCTGCGGGCCCCTTAGCCTGCCCTGCTTCCAAGCGA
CGGCCATCCCAGTAGGGGACTTTCCCACACTGTGCCTTTACGATCAGCGTGACAGAGTAG
AAGCTGGAGTGCCTCACCACACGGCCCGGAAACAGCGGGAAGTAACTGGAAAGAGCTTTA
GGACAGCTTAGATGCCGAGTGGGCGAATGCCAGACCAATGATACCCAGAGCTACCTGCCG
CCAACTTGTTGAGATGTGTGTTTGACTGTGAGAGAGTGTGTGTTTGTGTGTGTGTTTTGC
CATGAACTGTGGCCCCAGTGTATAGTGTTTCAGTGGGGGAGAAGCTGAAAGACCAAGACT
CTTCCCAAGTTAGCTTGTCTCCTCTCCTGTCACCCTAAGAGCCACTGAGTTGTGTAGGGA
TGAAGACTATTGAAGACTCCATTGCCAAACCATGGCCTTTCCTCAGTGTTGTAAGGCCTA
TGCCAAGGATAAAGGAAGGGTATGCCTTTGGGTACTCCAGGCACACACCTTTCTGAAATC
CTTCTCCAGCCAGCTGCTGCAGACAAAAGATCACATTTCTGGGAAGATGAGAACTTGTTT
CCAGACCAGCATCCAGTGGCCATCAGGTCTTGTGGCCCAAAGGCTATGCTTGCCTCCGGC
TGAGTGCCTGGGATAGGCCTTTTCTATGTCTCCCCAAGGCTGGGGTGCTGAGCCTGCCTT
CCTCACCACCTAGCCATAGTCTCAAACCTGTGGGGAAGGAGGTTTTCTCCCTGCCCGGGA
AGAGGACAGATAACTGATTTCCGTTCTTTTGACTGTGTTTTAAAATTCTCTTTCTAAACA
CAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAA
Restriction Sites ECoRI-NOT |
ACCN NM_005730
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_005730.3, NP_005721.3
RefSeq Size 5038 bp
RefSeq ORF 816 bp
Locus ID 10106
UniProt ID O14595
Cytogenetics 12q14.1
Domains CPDc
Protein Families Druggable Genome, Phosphatase
Summary Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.UniProtKB/Swiss-Prot Function
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Documents
Resources
"NM_005730" in other vectors (5)
SKU Description Size Price
RC209026 CTDSP2 (Myc-DDK-tagged)-Human CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 (CTDSP2) 10 ug
$300.00
RC209026L3 Lenti ORF clone of Human CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 (CTDSP2), Myc-DDK-tagged 10 ug
$600.00
RC209026L4 Lenti ORF clone of Human CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 (CTDSP2), mGFP tagged 10 ug
$600.00
RG209026 CTDSP2 (tGFP-tagged) - Human CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 (CTDSP2) 10 ug
$489.00 $500.00
SC128037 CTDSP2 (untagged)-Human CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 (CTDSP2) 10 ug
$300.00

file-alt Citations

Small carboxyl-terminal domain phosphatase 2 attenuates androgen-dependent transcription
Thompson, Lepikhova, Teixido-Travesa et al
EMBO J (2006) 25 (12), 2757-67 DOI: 10.1038/sj.emboj.7601161
Cited by 37
AI Summary: In this study, OriGene products—including the pCMV6-SCP2 expression plasmid and SCP2 shRNA constructs—were used to manipulate SCP2 levels in cells, enabling the authors to investigate how SCP2 modulates androgen receptor-dependent transcription.
Showing 1-1 of 1 papers.
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