SOX9 (NM_000346) Human Untagged Clone
$475.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | SOX9 |
| Synonyms | CMD1; CMPD1; SRA1; SRXX2; SRXY10 |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_000346 |
| Insert Size | 1530 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | no |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_000346.2, NP_000337.1 |
| RefSeq Size | 3935 bp |
| RefSeq ORF | 1530 bp |
| Locus ID | 6662 |
| UniProt ID | P48436 |
| Cytogenetics | 17q24.3 |
| Domains | HMG |
| Protein Families | Adult stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transcription Factors |
| Summary | The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. provided by RefSeq, Jul 2008 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_000346" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC208944 | SOX9 (Myc-DDK-tagged)-Human SRY (sex determining region Y)-box 9 (SOX9) | 10 ug |
$711.00
|
|
| RC208944L1 | Lenti-ORF clone of SOX9 (Myc-DDK-tagged)-Human SRY (sex determining region Y)-box 9 (SOX9) | 10 ug |
$1,011.00
|
|
| RC208944L2 | Lenti-ORF clone of SOX9 (mGFP-tagged)-Human SRY (sex determining region Y)-box 9 (SOX9) | 10 ug |
$1,011.00
|
|
| RC208944L3 | Lenti-ORF clone of SOX9 (Myc-DDK-tagged)-Human SRY (sex determining region Y)-box 9 (SOX9) | 10 ug |
$1,011.00
|
|
| RC208944L4 | Lenti-ORF clone of SOX9 (mGFP-tagged)-Human SRY (sex determining region Y)-box 9 (SOX9) | 10 ug |
$1,011.00
|
|
| RG208944 | SOX9 (tGFP-tagged) - Human SRY (sex determining region Y)-box 9 (SOX9) | 10 ug |
$911.00
|
|
Citations
Gene activated reinforced scaffolds for SOX9 delivery to enhance repair of large load bearing articular cartilage defects
Joyce, Hodgkinson, Intini et al
Eur Cell Mater (2024) 47, 91-108 DOI: 10.22203/ecm.v047a07
Joyce, Hodgkinson, Intini et al
Eur Cell Mater (2024) 47, 91-108 DOI: 10.22203/ecm.v047a07
Cited by 16
AI Summary: OriGene contributed the SOX9 plasmid (SC321884) used in this study to generate gene-activated scaffolds for enhanced cartilage repair.
Snippet: as supplied by OriGene (SC321884, OriGene, Rockville, MD,USA).Theplasmidwasamplified in chemically competent E.coli (ThermoFischer OneShot-C404010, USA), and isolated with an EndoFree Plas
aarF domain containing kinase 5 gene promotes invasion and migration of lung cancer cells through ADCK5-SOX9-PTTG1 pathway
Qiu, Li, Wang et al
Exp. Cell Res. (2020) 392 (1), 112002 DOI: 10.1016/j.yexcr.2020.112002
Qiu, Li, Wang et al
Exp. Cell Res. (2020) 392 (1), 112002 DOI: 10.1016/j.yexcr.2020.112002
Cited by 24
AI Summary: OriGene products, specifically the SOX9 WT (Cat. No. SC321884) and OE PTTG1 (Cat. No. RC211038) expression vectors, were used to investigate the roles of SOX9 and PTTG1 in the ADCK5-SOX9-PTTG1 pathway affecting lung cancer cell invasion and migration.
Snippet: Ala181) and siADCK5+ SOX9 S181A + OE PTTG1were obtained. The SOX9 WT and OE PTTG1 vectors were purchased from the Origene (Cat. … SC321884 and No. RC211038), and the SOX9 S181A site-directed mutant;- Ala181) and siADCK5+ SOX9 S181A + OE PTTG1were obtained. The SOX9 WT and OE PTTG1 vectors were purchased from the Origene (Cat. … SC321884 and No. RC211038), and the SOX9 S181A site-directed mutant
Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling
Leung, Mak, Kai et al
Oncotarget (2016) 7 (20), 29371-86 DOI: 10.18632/oncotarget.8835
Leung, Mak, Kai et al
Oncotarget (2016) 7 (20), 29371-86 DOI: 10.18632/oncotarget.8835
Cited by 80
AI Summary: OriGene’s Sox9 expression construct (SC321884: NM_000346, human cDNA clone) and empty vector were used for Sox9 overexpression studies in hepatocellular carcinoma cells to investigate its role in stemness and Wnt/β-catenin signaling.
Snippet: For overexpression study, either Sox9 expression construct (SC321884: NM_000346, human cDNA clone) or empty vector (Origene Technologies, Rockville, MD) were transfected into SMMC-7721 using Lipofectamine 2000
Sox9 expression in carcinogenesis and its clinical significance in intrahepatic cholangiocarcinoma
Matsushima, Kuroki, Kitasato et al
Dig Liver Dis (2015) 47 (12), 1067-75 DOI: 10.1016/j.dld.2015.08.003
Matsushima, Kuroki, Kitasato et al
Dig Liver Dis (2015) 47 (12), 1067-75 DOI: 10.1016/j.dld.2015.08.003
Cited by 35
AI Summary: OriGene's Sox9 cDNA ligated into the pCMV6 vector was used for gene transfection experiments in this study to investigate the molecular effects of Sox9 in intrahepatic cholangiocarcinoma cell lines.
Snippet: Gibco;Invitrogen, Carlsbad, CA). The Sox9 cDNA ligated into the pCMV6 vector was purchased from OriGene (Rockville, MD). As a negative control (Mock), a pCMV6 vector with no inser- tion was used. HuCCT1 and HuH28 ... Cite SaveSaving
SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma
Luanpitpong, Li, Manke et al
Oncogene (2015)
Luanpitpong, Li, Manke et al
Oncogene (2015)
Cited by 124
AI Summary: In this study, the SOX9 expression plasmid from OriGene was used to transfect human lung cancer cells, enabling the authors to investigate the role of SOX9 in cancer stem cell regulation and metastasis.
Snippet: H460 and A549 cells were transfected with SNAI2 (Addgene, plasmid 31698), 48 SOX9 (Origene, Rockville, MD, USA) or GFP (Invitrogen, Carlsbad, MA, USA) plasmid by nucleofection using Nucleofector (Amexa Biosystems, Cologne, Germany), according to the ... Cite SaveSaving
Sry-type HMG box 18 contributes to the differentiation of bone marrow-derived mesenchymal stem cells to endothelial cells
Ikhapoh, Pelham, Agrawal
Differentiation (2015)
Ikhapoh, Pelham, Agrawal
Differentiation (2015)
Cited by 22
Showing 1-6 of 14 papers.
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