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KRTCAP2 (NM_173852) Human Untagged Clone

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SKU
SC320977
KRTCAP2 (untagged)-Human keratinocyte associated protein 2 (KRTCAP2)
  $150.00
In Stock*
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Other products for "KRTCAP2 or NM_173852"

Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol KRTCAP2
Synonyms KCP2
Vector pCMV6-AC
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>OriGene sequence for NM_173852.3 GGGGGGAGTAGCAAGTCCGCGGTAAGCGCTGACGCATGCGCATAGCTAACCGCACCCGGT
TCAGCTCGCCTTTCTTGGCCAGAGGCGCCGGTTGGACTCACGGGCGGGGCATGATGGTGG
TGGGTACGGTCACCTCGCTGGCGCTCTCCTCCCTCCTGTCCCTGCTGCTCTTTGCTGGGA
TGCAGATGTACAGCCGTCAGCTGGCCTCCACCGAGTGGCTCACCATCCAGGGCGGCCTGC
TTGGTTCGGGTCTCTTCGTGTTCTCGCTCACTGCCTTCAATAATCTGGAGAATCTTGTCT
TTGGCAAAGGATTCCAAGCAAAGATCTTCCCTGAGATTCTCCTCTGCCTCCTGTTGGCTC
TCTTTGCATCTGGCCTCATCCACCGAGTCTGTGTCACCACCTGCTTCATCTTCTCCATGG
TTGGTCTGTACTACATCAACAAGATCTCCTCCACCCTGTACCAGGCAGCAGCTCCAGTCC
TCACACCAGCCAAGGTCACAGGCAAGAGCAAGAAGAGAAACTGACCCTGAATGTTCAATA
AAGTTGATTCTTCGAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Restriction Sites Please inquire |
ACCN NM_173852
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_173852.3, NP_776251.1
RefSeq Size 577 bp
RefSeq ORF 489 bp
Locus ID 200185
UniProt ID Q8N6L1
Cytogenetics 1q22
Protein Families Transmembrane
Summary Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (PubMed:22467853). May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1 (PubMed:21768116).UniProtKB/Swiss-Prot Function
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Documents
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"NM_173852" in other vectors (7)
SKU Description Size Price
RC208887 KRTCAP2 (Myc-DDK-tagged)-Human keratinocyte associated protein 2 (KRTCAP2) 10 ug
$150.00
RC208887L1 Lenti ORF clone of Human keratinocyte associated protein 2 (KRTCAP2), Myc-DDK-tagged 10 ug
$450.00
RC208887L2 Lenti ORF clone of Human keratinocyte associated protein 2 (KRTCAP2), mGFP tagged 10 ug
$450.00
RC208887L3 Lenti ORF clone of Human keratinocyte associated protein 2 (KRTCAP2), Myc-DDK-tagged 10 ug
$450.00
RC208887L4 Lenti ORF clone of Human keratinocyte associated protein 2 (KRTCAP2), mGFP tagged 10 ug
$450.00
RG208887 KRTCAP2 (tGFP-tagged) - Human keratinocyte associated protein 2 (KRTCAP2) 10 ug
$350.00
SC101215 KRTCAP2 (untagged)-Human keratinocyte associated protein 2 (KRTCAP2) 10 ug
$150.00

file-alt Citations

Keratinocyte-associated protein 2 is a bona fide subunit of the mammalian oligosaccharyltransferase
Roboti, High
J. Cell. Sci. (2012) 125 (Pt 1), 220-32 DOI: 10.1242/jcs.094599
Cited by 35
AI Summary: In this study, OriGene products—including the KCP2 cDNA clone and anti-KCP2 antibody—were used to express and detect KCP2, enabling the authors to characterize its structure, localization, and interaction with oligosaccharyltransferase complex subunits.
Snippet: TM) domains (Fig. 1, TM1–TM3). However, the TMHMM algorithm (Sonnhammer et al., 1998) has predicted the final hydrophobic stretch as two short TM domains, resulting in a model with four TM spans. Amino acid sequence
Showing 1-1 of 1 papers.
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