FOXM1 (NM_202002) Human Untagged Clone
$1,101.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | FOXM1 |
| Synonyms | FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11; HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29; TRIDENT |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_202002 |
| Insert Size | 3500 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | It is not a varient. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_202002.1, NP_973731.1 |
| RefSeq Size | 3641 bp |
| RefSeq ORF | 2406 bp |
| Locus ID | 2305 |
| UniProt ID | Q08050 |
| Cytogenetics | 12p13.33 |
| Protein Families | Transcription Factors |
| Summary | The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jul 2011 Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_202002" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC211450 | FOXM1 (Myc-DDK-tagged)-Human forkhead box M1 (FOXM1), transcript variant 1 | 10 ug |
$1,100.00
|
|
| RC211450L1 | Lenti-ORF clone of FOXM1 (Myc-DDK-tagged)-Human forkhead box M1 (FOXM1), transcript variant 1 | 10 ug |
$1,400.00
|
|
| RC211450L2 | Lenti-ORF clone of FOXM1 (mGFP-tagged)-Human forkhead box M1 (FOXM1), transcript variant 1 | 10 ug |
$1,400.00
|
|
| RC211450L3 | Lenti-ORF clone of FOXM1 (Myc-DDK-tagged)-Human forkhead box M1 (FOXM1), transcript variant 1 | 10 ug |
$1,400.00
|
|
| RC211450L4 | Lenti-ORF clone of FOXM1 (mGFP-tagged)-Human forkhead box M1 (FOXM1), transcript variant 1 | 10 ug |
$1,400.00
|
|
| RG211450 | FOXM1 (tGFP-tagged) - Human forkhead box M1 (FOXM1), transcript variant 1 | 10 ug |
$1,300.00
|
|
Citations
FOXM1 contributes to taxane resistance by regulating UHRF1-controlled cancer cell stemness
Yuan, Liu, Yu et al
Cell Death Dis (2018) 9 (5), 562 DOI: 10.1038/s41419-018-0631-9
Yuan, Liu, Yu et al
Cell Death Dis (2018) 9 (5), 562 DOI: 10.1038/s41419-018-0631-9
AI Summary: OriGene products contributed to this study by providing FOXM1 and UHRF1 cDNAs in pCMV-XL5 vectors, which were used to investigate the roles of these genes in taxane resistance and cancer stem cell regulation.
Snippet: ersity. These cells were cultured in RPMI-1640 media supplemented with 10% FBS and 1% streptomycin/penicillin. Plasmids, siRNA, and shRNA FOXM1 and UHRF1 cDNAs in pCMV-XL5 vector were purchased from Origene (Rockville, MD, USA). A 2000 bp uhrf1 gene promoter was obtained by the PCR method using genomic DNA as the template, and then subcloned to PCR2.1 vector (Thermo Fisher Scientific, Shanghai,
FOXM1 promotes the progression of prostate cancer by regulating PSA gene transcription
Liu, Liu, Yuan et al
Oncotarget (2017) 8 (10), 17027-17037 DOI: 10.18632/oncotarget.15224
Liu, Liu, Yuan et al
Oncotarget (2017) 8 (10), 17027-17037 DOI: 10.18632/oncotarget.15224
Snippet: FOXM1 and AR cDNAs in the pCMV-XL5 vector were purchased from Origene (Rockville, MD, USA). pDRIVE01-PSAenh/prom(h)v04, containing a PSA gene enhancer (1582bp) and promoter (670 bp), was purchased from InvivoGen (San Diego, CA, USA)
Insulin-like growth factor-1 receptor signaling increases the invasive potential of HER2-overexpressing breast cancer cells via Src-FAK and FoxM1
Sanabria-Figueroa, Donnelly, Foy et al
Mol. Pharmacol. (2014)
Sanabria-Figueroa, Donnelly, Foy et al
Mol. Pharmacol. (2014)
Cited by 50
AI Summary: In this study, the OriGene FoxM1 expression plasmid was used to re-express FoxM1 in breast cancer cells, enabling the authors to demonstrate that FoxM1 restoration rescues the invasive potential of IGF-1R knockdown, thereby elucidating FoxM1’s role in IGF-1R/HER2-mediated cancer cell invasion.
Phenotype-assisted transcriptome analysis identifies FOXM1 downstream from Ras-MKK3-p38 to regulate in vitro cellular invasion
Behren, Mühlen, Acuna Sanhueza et al
Oncogene (2010) 29 (10), 1519-30 DOI: 10.1038/onc.2009.436
Behren, Mühlen, Acuna Sanhueza et al
Oncogene (2010) 29 (10), 1519-30 DOI: 10.1038/onc.2009.436
Cited by 40
AI Summary: OriGene products contributed to this study by providing the MKK3(act) cDNA construct used for stable transfection of NIH3T3 fibroblasts and the FOXM1 shRNA used for RNA knockdown experiments, enabling the authors to investigate the role of FOXM1 in Ras-MKK3-p38-mediated cellular invasion.
Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC
Calvisi, Pinna, Ladu et al
Gut (2009) 58 (5), 679-87 DOI: 10.1136/gut.2008.152652
Calvisi, Pinna, Ladu et al
Gut (2009) 58 (5), 679-87 DOI: 10.1136/gut.2008.152652
Cited by 91
AI Summary: In this study, OriGene's human FOXM1 cDNA clone (SC119401) and FOXM1 shRNA plasmids (TG313165) were used to overexpress and silence FOXM1 in human HCC cell lines, respectively, enabling the researchers to demonstrate FOXM1's role in promoting cell proliferation, angiogenesis, and ERK activity in hepatocellular carcinoma.
Down-regulation of Forkhead Box M1 transcription factor leads to the inhibition of invasion and angiogenesis of pancreatic cancer cells
Wang, Banerjee, Kong et al
Cancer Res (2007) 67 (17), 8293-300 DOI: 10.1158/0008-5472.CAN-07-1265
Wang, Banerjee, Kong et al
Cancer Res (2007) 67 (17), 8293-300 DOI: 10.1158/0008-5472.CAN-07-1265
Showing 1-6 of 6 papers.
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