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IFITM1 (NM_003641) Human Untagged Clone

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SKU
SC117830
IFITM1 (untagged)-Human interferon induced transmembrane protein 1 (9-27) (IFITM1)
  $150.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol IFITM1
Synonyms 9-27; CD225; DSPA2a; IFI17; LEU13
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC117830 sequence for NM_003641 edited (data generated by NextGen Sequencing)
ATGCACAAGGAGGAACATGAGGTGGCTGTGCTGGGGGCACCCCCCAGCACCATCCTTCCA
AGGTCCACCGTGATCAACATCCACAGCGAGACCTCCGTGCCCGACCATGTCGTCTGGTCC
CTGTTCAACACCCTCTTCTTGAACTGGTGCTGTCTGGGCTTCATAGCATTCGCCTACTCC
GTGAAGTCTAGGGACAGGAAGATGGTTGGCGACGTGACCGGGGCCCAGGCCTATGCCTCC
ACCGCCAAGTGCCTGAACATCTGGGCCCTGATTCTGGGCATCCTCATGACCATTGGATTC
ATCCTGTTACTGGTATTCGGCTCTGTGACAGTCTACCATATTATGTTACAGATAATACAG
GAAAAACGGGGTTACTAG

Clone variation with respect to NM_003641.3
5' Read Nucleotide Sequence
>OriGene 5' read for NM_003641 unedited
ATTTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGGTCTCACTGAGCACCG
TCCCAGCATCCGGACACCACAGCGGCCCTTCGCTCCACGCAGAAAACCACACTTCTCAAA
CCTTCACTCAACACTTCCTTCCCCAAAGCCAGAAGATGCACAAGGAGGAACATGAGGTGG
CTGTGCTGGGGGCACCCCCCAGCACCATCCTTCCAAGGTCCACCGTGATCAACATCCACA
GCGAGACCTCCGTGCCCGACCATGTCGTCTGGTCCCTGTTCAACACCCTCTTCTTGAACT
GGTGCTGTCTGGGCTTCATAGCATTCGCCTACTCCGTGAAGTCTAGGGACAGGAAGATGG
TTGGCGACGTGACCGGGGCCCAGGCCTATGCCTCCACCGCCAAGTGCCTGAACATCTGGG
CCCTGATTCTGGGCATCCTCATGACCATTGGATTCATCCTGTTACTGGTATTCGGCTCTG
TGACAGTCTACCATATTATGTTACAGATAATACAGGAAAAACGGGGTTACTAGTAGCCGC
CCATAGCCTGCAACCTTTGCACTCCACTGTGCAATGCTGGCCCTGCACGCTGGGGCTGTT
GCCCCTGCCCCCTTGGTCCTGCCCCTAGATACAGCAGTTTATACCCACACACCTGTCTAC
AGTGTCATTCAATAAAGTGCACGTGCTTGTGAANAANAAAAANNNNNNNNANNANAAAAA
CTCGACTCTAGATTGCGGCCGCGGTCATAGCTGTTTCCTGAACAGATCCCGGGTGGCATC
CCTGTGACCCCTCCCCAGTGCCTCTCCTGGCCCCTGNAAAGTGCCACTCCAGTGCCCACC
AGCCTTGTCCTAATAAAAATAAAGTGCATCATTTTGTCTGACTAGGGGTNCCTCTATATA
TATGGTGGAGGGGGGN
3' Read Nucleotide Sequence
>OriGene 3' read for NM_003641 unedited
GGCTTACTTGNACGCGGCCGCATTCTANATCGAGNTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTAACAACCACGTGCACTTTATTGAATGACACTGTAAACAGGTGTGTGGGTATAAACT
GCTGTATCTAGGGGCAGGACCAAGGGGGCAGGGGCAACAGCCCCAGCGTGCAGGGCCAGC
ATTGCACAGGGGAGTGCAAAGGTTGCAGGCTATGGGCGGTTACTAGTAACCCCGTTTTTC
CTGTATTATCTGCAACATAATATGGTAAACTGTCACAGAGCCGAATACCAGTAACAGGAT
GAATCCAATGGTCATGAGGATGCCCAAAATCAGGGCCCAAATGTTCAGGCACTTGGCGGG
GGAGGCATAGGCCTGGGCCCCGGTCACGTCGCCAACCATCTTCCTGTCCCTAAACTTAAC
GGAGTAGGCGAATGCTATGAAGCCCAAACAGCACCAGTTCAAAAAAAGGGTGTTGAACAG
GGACCAAACAACATGGCCGGGCACGGAGGTCTTGTTGTGGATGTTGATCACGGCGGACCT
TGAAAGGATGGTGCTGGGGGGGTCCCCTCCGCACACTCACCTTCCCGTCTTTCCTTGTGC
CCCTCCTTGCTCCGCCGAACGTACTTTTCCTCCACCCCTTCCCCCTCTCCCTCTCCCCCC
CCCCTCCCCTCTCTTCTTTCTTTCTTCCTACCATTCTTTACTCCCATCCTTCCCCTCCCT
TCTTTCCTTCCCTTTCCCCCTCATCCCTTCATTCCCTTCTTCTCCTTTTCCCCCCCACCA
CCCCTCCCTCTTATCCCCCTCCACTATCATATCCCATCCATCCTCTACCTTTCCCCCCTA
TTCCCTTTCTCCTCCTCTCCTCCTCCCCAATACTTCTCTCATTCAGCACGTCTCCCCCCT
TCCCCTCAATTCT
Restriction Sites NotI-NotI |
ACCN NM_003641
Insert Size 1180 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_003641.2, NP_003632.2
RefSeq Size 853 bp
RefSeq ORF 378 bp
Locus ID 8519
UniProt ID P13164
Cytogenetics 11p15.5
Domains CD225
Protein Families Druggable Genome, Transmembrane
Protein Pathways B cell receptor signaling pathway
Summary IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation.UniProtKB/Swiss-Prot Function
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Documents
Resources
"NM_003641" in other vectors (6)
SKU Description Size Price
RC201617 IFITM1 (Myc-DDK-tagged)-Human interferon induced transmembrane protein 1 (9-27) (IFITM1) 10 ug
$150.00
RC201617L1 Lenti ORF clone of Human interferon induced transmembrane protein 1 (9-27) (IFITM1), Myc-DDK-tagged 10 ug
$450.00
RC201617L2 Lenti ORF clone of Human interferon induced transmembrane protein 1 (9-27) (IFITM1), mGFP tagged 10 ug
$450.00
RC201617L3 Lenti ORF clone of Human interferon induced transmembrane protein 1 (9-27) (IFITM1), Myc-DDK-tagged 10 ug
$450.00
RC201617L4 Lenti ORF clone of Human interferon induced transmembrane protein 1 (9-27) (IFITM1), mGFP tagged 10 ug
$450.00
RG201617 IFITM1 (tGFP-tagged) - Human interferon induced transmembrane protein 1 (9-27) (IFITM1) 10 ug
$489.00

file-alt Citations

IFITM3 Reduces Retroviral Envelope Abundance and Function and Is Counteracted by glycoGag
Ahi, Yimer, Shi et al
mBio (2020) 11 (1) DOI: 10.1128/mBio.03088-19
AI Summary: OriGene products pCMV6-XL5 encoding untagged human IFITM1 (SC117830), IFITM2 (SC124192), and IFITM3 (SC112616) were used to express these IFITM proteins in cells, enabling the authors to investigate their roles in reducing retroviral envelope abundance and function.
Snippet: …pCMV6-XL5 encoding untagged human IFITM1, IFITM2, or IFITM3 was purchased from Origene (SC117830, SC124192, and SC112616). pQCXIP encoding FLAG-Ifitm3 was obtained from Chen Liang (McGill University). … pCMV6-XL5 encoding untagged human IFITM1, IFITM2, or IFITM3 was purchased from Origene (SC117830, SC124192, and SC112616). pQCXIP encoding FLAG-Ifitm3 was obtained from Chen Liang (McGill University). …
Showing 1-1 of 1 papers.
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