PD1 (PDCD1) (NM_005018) Human Untagged Clone
$450.00
5 Days*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | PD1 |
| Synonyms | CD279; hPD-1; hPD-l; hSLE1; PD-1; PD1; SLEB2 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_005018 |
| Insert Size | 867 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_005018.1, NP_005009.1 |
| RefSeq Size | 2106 bp |
| RefSeq ORF | 867 bp |
| Locus ID | 5133 |
| UniProt ID | Q15116, A0A0M3M0G7 |
| Cytogenetics | 2q37.3 |
| Domains | ig, IG, IGv |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Cell adhesion molecules (CAMs), T cell receptor signaling pathway |
| Summary | Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. provided by RefSeq, Aug 2020 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_005018" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC210364 | PD-1 / PDCD1 (Myc-DDK-tagged)-Human programmed cell death 1 (PD-1 / PDCD1) | 10 ug |
$450.00
|
|
| RC210364L1 | Lenti ORF clone of Human programmed cell death 1 (PDCD1), Myc-DDK-tagged | 10 ug |
$750.00
|
|
| RC210364L2 | Lenti ORF clone of Human programmed cell death 1 (PDCD1), mGFP tagged | 10 ug |
$750.00
|
|
| RC210364L3 | Lenti ORF clone of Human programmed cell death 1 (PDCD1), Myc-DDK-tagged | 10 ug |
$750.00
|
|
| RC210364L4 | Lenti ORF clone of Human programmed cell death 1 (PDCD1), mGFP tagged | 10 ug |
$750.00
|
|
| RG210364 | PD-1 / PDCD1 (tGFP-tagged) - Human programmed cell death 1 (PD-1 / PDCD1) | 10 ug |
$489.00
$650.00
|
|
Citations
PD-1 independent of PD-L1 ligation promotes glioblastoma growth through the NFκB pathway
Mirzaei, Gordon, Zemp et al
Sci Adv (2021) 7 (45), eabh2148 DOI: 10.1126/sciadv.abh2148
Mirzaei, Gordon, Zemp et al
Sci Adv (2021) 7 (45), eabh2148 DOI: 10.1126/sciadv.abh2148
Cited by 37
AI Summary: In this paper, OriGene products—specifically the PDCD1 (PD-1) Human cDNA ORF Clone and PDCD1 shRNA lentiviral particles—were used to manipulate PD-1 expression in glioblastoma cells, enabling the authors to investigate the role of tumor-intrinsic PD-1 in promoting glioblastoma growth via the NFκB pathway.
Snippet: GBM microenvironment accelerated sphere-forming capacity and proliferation of BTICs, as well as intracranial tumor growth in a mouse GBM model. The specific contribution of tumor-intrinsic PD-1 to tumorigenesis appears to be context dependent, and therefore, studying the tumor-intrinsic functions of PD-1 is of high interest in the field of targeted cancer therapies. Although PD-1 effects on the p
Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells
Franchini, Lanvin, Tosolini et al
Cell Rep (2019) 26 (1), 94-107.e7 DOI: 10.1016/j.celrep.2018.12.014
Franchini, Lanvin, Tosolini et al
Cell Rep (2019) 26 (1), 94-107.e7 DOI: 10.1016/j.celrep.2018.12.014
PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1
Chen, Kim, Li et al
Nat. Neurosci. (2017)
Chen, Kim, Li et al
Nat. Neurosci. (2017)
Showing 1-3 of 3 papers.
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