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Androgen Receptor (AR) (NM_000044) Human Tagged ORF Clone

  • TrueORF®
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SKU
RG215316
AR (tGFP-tagged) - Human androgen receptor (AR), OriGene unique variant
ORF Plasmid:
tGFP DDK
Lentiviral Particles:
DDK mGFP DDK w/ Puro mGFP w/ Puro
$789.00 $1,040.00
In Stock*
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Other products for "Androgen Receptor or NM_000044"

Specifications
Specifications
Product Data
Type Human Tagged ORF Clone
Target Symbol Androgen Receptor
Synonyms AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM
Vector pCMV6-AC-GFP
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection Neomycin
Restriction Sites SgfI-MluI Cloning Scheme for this gene | Plasmid Map
ACCN NM_000044
ORF Size 2691 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq Size 4314 bp
RefSeq ORF 2763 bp
Locus ID 367
UniProt ID P10275
Cytogenetics Xq12
Domains Androgen_recep, HOLI, zf-C4
Protein Families Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
Protein Pathways Oocyte meiosis, Pathways in cancer, Prostate cancer
MW 98.3 kDa
Summary The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Jan 2017
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"NM_000044" in other vectors (13)
SKU Description Size Price
RC215316 AR (Myc-DDK-tagged)-Human androgen receptor (AR), OriGene unique variant 1 10 ug
$589.00 $840.00
RC215316L1 Lenti ORF clone of Human androgen receptor (AR), OriGene unique variant 1, Myc-DDK-tagged 10 ug
$1,140.00
RC215316L2 Lenti ORF clone of Human androgen receptor (AR), OriGene unique variant, mGFP tagged 10 ug
$1,140.00
RC215316L3 Lenti ORF clone of Human androgen receptor (AR), OriGene unique variant 1, Myc-DDK-tagged 10 ug
$1,140.00
RC215316L4 Lenti ORF clone of Human androgen receptor (AR), OriGene unique variant, mGFP tagged 10 ug
$1,140.00
RC235415 AR (Myc-DDK-tagged)-Human androgen receptor (AR), transcript variant 1 10 ug
$589.00 $1,263.00
RC235415L1 Lenti ORF clone of Human androgen receptor (AR), transcript variant 1, Myc-DDK-tagged 10 ug
$1,563.00
RC235415L2 Lenti ORF clone of Human androgen receptor (AR), transcript variant 1, mGFP tagged 10 ug
$1,563.00
RC235415L3 Lenti ORF clone of Human androgen receptor (AR), transcript variant 1, Myc-DDK-tagged 10 ug
$1,563.00
RC235415L4 Lenti ORF clone of Human androgen receptor (AR), transcript variant 1, mGFP tagged 10 ug
$1,563.00
RG235415 AR (tGFP-tagged) - Human androgen receptor (AR), transcript variant 1 10 ug
$789.00 $1,463.00
SC114220 AR (untagged)-Human androgen receptor (AR), OriGene unique variant 1 10 ug
$1,265.00
SC333310 AR (untagged)-Human androgen receptor (AR), transcript variant 1 10 ug
$1,349.00

Plasmid Map for RG215316

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Cloning scheme for RG215316
Circular map for RG215316

file-alt Citations

Mutational analysis of the androgen receptor (NR3C4) gene in patients with 46,XY DSD
Ramos, Chávez, Mares et al
Gene (2017)
AI Summary: In this study, the OriGene pCMV6-AC-GFP vector containing human AR cDNA was used to generate and express mutant androgen receptor proteins in HEK293 cells, enabling functional analysis of newly identified AR gene mutations in patients with 46,XY DSD.
Snippet: New, unreported AR mutations were generated and transiently expressed in HEK293 cells to investigate their binding activity. The commercial vector pCMV6-AC-GFP (OriGene Technologies Inc., Rockville, MD) containing human AR cDNA (Cat. … New, unreported AR mutations were generated and transiently expressed in HEK293 cells to investigate their binding activity. The commercial vector pCMV6-AC-GFP (OriGene Technologies Inc., Rockville, MD) containing human AR cDNA (Cat. … New, unreported AR mutations were generated and transiently expressed in HEK293 cells to investigate their binding activity. The commercial vector pCMV6-AC-GFP (OriGene Technologies Inc., Rockville, MD) containing human AR cDNA (Cat. …
Showing 1-1 of 1 papers.
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