TBC1D23 (NM_018309) Human Tagged ORF Clone
SKU
RC220480
TBC1D23 (Myc-DDK-tagged)-Human TBC1 domain family, member 23 (TBC1D23), transcript variant 2
$626.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | TBC1D23 |
| Synonyms | NS4ATP1; PCH11 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_018309 |
| ORF Size | 2052 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_018309.5 |
| RefSeq Size | 2065 bp |
| RefSeq ORF | 2055 bp |
| Locus ID | 55773 |
| UniProt ID | Q9NUY8 |
| Cytogenetics | 3q12.1-q12.2 |
| Domains | TBC |
| Protein Families | Druggable Genome |
| MW | 76.3 kDa |
| Summary | Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity).UniProtKB/Swiss-Prot Function |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_018309" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC220480L3 | Lenti ORF clone of Human TBC1 domain family, member 23 (TBC1D23), transcript variant 2, Myc-DDK-tagged | 10 ug |
$926.00
|
|
| RC220480L4 | Lenti ORF clone of Human TBC1 domain family, member 23 (TBC1D23), transcript variant 2, mGFP tagged | 10 ug |
$926.00
|
|
| RG220480 | TBC1D23 (tGFP-tagged) - Human TBC1 domain family, member 23 (TBC1D23), transcript variant 2 | 10 ug |
$826.00
|
|
| SC310172 | TBC1D23 (untagged)-Human TBC1 domain family, member 23 (TBC1D23), transcript variant 2 | 10 ug |
$690.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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