LRP6 (NM_002336) Human Tagged ORF Clone
$589.00
$2,069.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | LRP6 |
| Synonyms | ADCAD2; STHAG7 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_002336 |
| ORF Size | 4839 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_002336.1, NP_002327.1 |
| RefSeq Size | 5301 bp |
| RefSeq ORF | 4842 bp |
| Locus ID | 4040 |
| UniProt ID | O75581 |
| Cytogenetics | 12p13.2 |
| Domains | EGF, ldl_recept_a, ldl_recept_b |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Wnt signaling pathway |
| MW | 180.44 kDa |
| Summary | This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.provided by RefSeq, Dec 2009 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_002336" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC218918L1 | Lenti ORF clone of Human low density lipoprotein receptor-related protein 6 (LRP6), Myc-DDK-tagged | 10 ug |
$2,369.00
|
|
| RC218918L2 | Lenti ORF clone of Human low density lipoprotein receptor-related protein 6 (LRP6), mGFP tagged | 10 ug |
$2,369.00
|
|
| RC218918L3 | Lenti ORF clone of Human low density lipoprotein receptor-related protein 6 (LRP6), Myc-DDK-tagged | 10 ug |
$2,369.00
|
|
| RC218918L4 | Lenti ORF clone of Human low density lipoprotein receptor-related protein 6 (LRP6), mGFP tagged | 10 ug |
$2,369.00
|
|
| RG218918 | LRP6 (tGFP-tagged) - Human low density lipoprotein receptor-related protein 6 (LRP6) | 10 ug |
$789.00
$2,269.00
|
|
| SC315373 | LRP6 (untagged)-Human low density lipoprotein receptor-related protein 6 (LRP6) | 10 ug |
$2,070.00
|
|
Citations
Evaluation of the cellular impact of missense variants in low-density lipoprotein receptor-related protein 6 (LRP6) associated with cardiovascular diseases in HeLa and HEK293T cell lines
Raj, Samha, Badawi et al
Front Cell Dev Biol (2026) 14, 1828772-1828772 DOI: 10.3389/fcell.2026.1828772
Raj, Samha, Badawi et al
Front Cell Dev Biol (2026) 14, 1828772-1828772 DOI: 10.3389/fcell.2026.1828772
AI Summary: OriGene’s human LRP6 ORF clone (pCMV6-Entry Myc-DDK-tagged plasmid, CAT#: RC218918) was used as the template for generating LRP6 missense variants, enabling the study of their cellular localization, stability, and impact in the context of cardiovascular disease.
Snippet: >Primer’s design and site-directed mutagenesis for the generation of LRP6 missense variantsThe human LRP6 ORF clone inserted into the pCMV6-Entry Myc-DDK-tagged plasmid was obtained from OriGene Technologies, Inc. (Rockville, MD, USA), CAT#: RC218918. To create a specific missense mutation in the double-stranded plasmid, mutagenic primers for the selected mutations were designed using
Matrix metalloproteinase-14 promotes LRP6 shedding in vascular smooth muscle cells and its expression is elevated in the tibial arteries from peripheral artery disease
Chen, Gao, Zeng et al
Biochim Biophys Acta Gen Subj (2026) 1870 (8), 130964 DOI: 10.1016/j.bbagen.2026.130964
Chen, Gao, Zeng et al
Biochim Biophys Acta Gen Subj (2026) 1870 (8), 130964 DOI: 10.1016/j.bbagen.2026.130964
Cited by 1
The LRP6 functional mutation rs2302685 contributes to individual susceptibility to alcoholic liver injury related to the Wnt/β-catenin-TCF1-CYP2E1 signaling pathway
Xu, Chen, Lin et al
Arch. Toxicol. (2019)
Xu, Chen, Lin et al
Arch. Toxicol. (2019)
Low-density lipoprotein receptor-related protein 6 regulates alternative pre-mRNA splicing
Yuan, Wang, Hu et al
J. Cell. Mol. Med. (2018)
Yuan, Wang, Hu et al
J. Cell. Mol. Med. (2018)
AI Summary: OriGene products contributed to this study by providing the Lrp6 plasmid and the pCMV6-entry vector, which were used for gene amplification and construction of minigene expression constructs to investigate the role of LRP6 in alternative pre-mRNA splicing.
Snippet: The corresponding sequence was amplified from Lrp6 plasmid (Origene) by PCR and was subcloned into the pcDNA3.1 expression vector (Invitrogen) using BamH1 and Xbal restriction sites The minigene constructs were assembled in the pCMV6-entry vector (Origene
Cell-type specific potent Wnt signaling blockade by bispecific antibody
Lee, Zhang, Su et al
Sci Rep (2018) 8 (1), 766 DOI: 10.1038/s41598-017-17539-z
Lee, Zhang, Su et al
Sci Rep (2018) 8 (1), 766 DOI: 10.1038/s41598-017-17539-z
AI Summary: OriGene products, specifically full-length human LRP6, ICAM-1, and EphA2 cDNA cloned into pCMV-Entry, were used for sub-cloning or transient transfection to facilitate the development and testing of bispecific antibodies for cell type-selective Wnt signaling blockade in this study.
Snippet: …A notable difference between our guide/effector approach and oth;Full-length human LRP6, ICAM-1, or EphA2 cDNA cloned into pCMV-Entry (Origene) were used for sub-cloning or transient transfection. pFUSE-hIgG1-Fc2 (InvivoGen) was used for Fc-fusion constructs of truncated LRP6E1E2 and LRP6E3E4 domains. …
microRNA-454 shows anti-angiogenic and anti-metastatic activity in pancreatic ductal adenocarcinoma by targeting LRP6
Fan, Shi, Li et al
Am J Cancer Res (2017) 7 (1), 139-147
Fan, Shi, Li et al
Am J Cancer Res (2017) 7 (1), 139-147
Showing 1-6 of 6 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
