LRP6 (NM_002336) Human Tagged ORF Clone Lentiviral Particle

SKU RC218918L4V

Lenti ORF particles, LRP6 (mGFP-tagged) - Human low density lipoprotein receptor-related protein 6 (LRP6), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: LRP6
• Synonyms: ADCAD2; STHAG7
• Vector: pLenti-C-mGFP-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC218918).
• ACCN: NM_002336
• ORF Size: 4839 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_002336.1, NP_002327.1
• RefSeq Size: 5301 bp
• RefSeq ORF: 4842 bp
• Locus ID: 4040
• UniProt ID: O75581
• Cytogenetics: 12p13.2
• Domains: EGF, ldl_recept_a, ldl_recept_b
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Wnt signaling pathway
• MW: 180.44 kDa
• Summary: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]