S2P (MBTPS2) (NM_015884) Human Tagged ORF Clone
SKU
RC218791
MBTPS2 (Myc-DDK-tagged)-Human membrane-bound transcription factor peptidase, site 2 (MBTPS2)
$725.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | S2P |
| Synonyms | BRESEK; IFAP; KFSD; KFSDX; OI19; OLMSX; S2P |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_015884 |
| ORF Size | 1557 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_015884.4 |
| RefSeq Size | 1759 bp |
| RefSeq ORF | 1560 bp |
| Locus ID | 51360 |
| UniProt ID | O43462 |
| Cytogenetics | Xp22.12 |
| Domains | Peptidase_M50 |
| Protein Families | Druggable Genome, Protease, Transmembrane |
| MW | 57.3 kDa |
| Summary | This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.provided by RefSeq, Aug 2009 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_015884" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC218791L1 | Lenti ORF clone of Human membrane-bound transcription factor peptidase, site 2 (MBTPS2), Myc-DDK-tagged | 10 ug |
$1,025.00
|
|
| RC218791L2 | Lenti ORF clone of Human membrane-bound transcription factor peptidase, site 2 (MBTPS2), mGFP tagged | 10 ug |
$1,025.00
|
|
| RC218791L3 | Lenti ORF clone of Human membrane-bound transcription factor peptidase, site 2 (MBTPS2), Myc-DDK-tagged | 10 ug |
$1,025.00
|
|
| RC218791L4 | Lenti ORF clone of Human membrane-bound transcription factor peptidase, site 2 (MBTPS2), mGFP tagged | 10 ug |
$1,025.00
|
|
| RG218791 | MBTPS2 (tGFP-tagged) - Human membrane-bound transcription factor peptidase, site 2 (MBTPS2) | 10 ug |
$925.00
|
|
| SC114571 | MBTPS2 (untagged)-Human membrane-bound transcription factor peptidase, site 2 (MBTPS2) | 10 ug |
$726.00
|
|
Citations
A novel MBTPS2 variant associated with BRESHECK syndrome impairs sterol-regulated transcription and the endoplasmic reticulum stress response
Strong, March, Cardinale et al
Am J Med Genet A (2021)
Strong, March, Cardinale et al
Am J Med Genet A (2021)
Cited by 5
Understanding the phenotypic similarities between IFAP and Olmsted syndrome from a molecular perspective: the interaction of MBTPS2 and TRPV3
Nemer, Safi, Kreidieh et al
Arch. Dermatol. Res. (2017)
Nemer, Safi, Kreidieh et al
Arch. Dermatol. Res. (2017)
AI Summary: OriGene's pCMV6-Entry plasmid containing the human MBTPS2 gene was used to generate and study the effects of the identified mutation, enabling the researchers to investigate the molecular interactions underlying IFAP and Olmsted syndromes.
Snippet: After identifying the p.F475S (c.1621T > C) mutation in MBTPS2 gene sequence, an oligonucleotide encoding the desired mutation was annealed to one strand of the human MBTPS2 gene cloned in pCMV6-Entry plasmid (Origene, Rockville, USA) and was considered ... … After identifying the p.F475S (c.1621T > C) mutation in MBTPS2 gene sequence, an oligonucleotide encoding the desired mutation was annealed to one strand of the human MBTPS2 gene cloned in pCMV6-Entry plasmid (Origene, Rockville, USA) and was considered ... …
Showing 1-2 of 2 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
