ROR2 (NM_004560) Human Tagged ORF Clone
$1,295.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | ROR2 |
| Synonyms | BDB; BDB1; NTRKR2 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_004560 |
| ORF Size | 2829 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_004560.4 |
| RefSeq Size | 4091 bp |
| RefSeq ORF | 2832 bp |
| Locus ID | 4920 |
| UniProt ID | Q01974 |
| Cytogenetics | 9q22.31 |
| Protein Families | Druggable Genome, Protein Kinase, Transmembrane |
| MW | 104.74 kDa |
| Summary | The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. provided by RefSeq, Jul 2008 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_004560" in other vectors (8)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC215640L1 | Lenti ORF clone of Human receptor tyrosine kinase-like orphan receptor 2 (ROR2), Myc-DDK-tagged | 10 ug |
$1,595.00
|
|
| RC215640L2 | Lenti ORF clone of Human receptor tyrosine kinase-like orphan receptor 2 (ROR2), mGFP tagged | 10 ug |
$1,595.00
|
|
| RC215640L3 | Lenti ORF clone of Human receptor tyrosine kinase-like orphan receptor 2 (ROR2), Myc-DDK-tagged | 10 ug |
$1,595.00
|
|
| RC215640L4 | Lenti ORF clone of Human receptor tyrosine kinase-like orphan receptor 2 (ROR2), mGFP tagged | 10 ug |
$1,595.00
|
|
| RC600060 | ROR2 (DDK-His-tagged)-Extra Cellular Domain Clone of Homo sapiens receptor tyrosine kinase-like orphan receptor 2, Signal peptide (1-33) plus EC domain (34-403) | 10 ug |
$289.00
$457.00
|
|
| RG215640 | ROR2 (tGFP-tagged) - Human receptor tyrosine kinase-like orphan receptor 2 (ROR2) | 10 ug |
$1,495.00
|
|
| SC117279 | ROR2 (untagged)-Human receptor tyrosine kinase-like orphan receptor 2 (ROR2) | 10 ug |
$1,296.00
|
|
| SC323522 | ROR2 (untagged)-Kinase deficient mutant (K507M) of Human receptor tyrosine kinase-like orphan receptor 2 (ROR2) | 10 ug |
$1,296.00
|
|
Citations
Targeting ROR2 homooligomerization disrupts ROR2-dependent signaling and suppresses stem-like cell properties of human breast adenocarcinoma
Leng, Huang, Wu et al
iScience (2024) 28 (1), 111589-111589 DOI: 10.1016/j.isci.2024.111589
Leng, Huang, Wu et al
iScience (2024) 28 (1), 111589-111589 DOI: 10.1016/j.isci.2024.111589
Cited by 3
AI Summary: OriGene's Human ROR2 ORF plasmids (RC215640) were used in this study to manipulate ROR2 expression, enabling the investigation of ROR2-dependent signaling and its role in the stem-like properties of human breast adenocarcinoma cells.
Snippet: Human ROR2 ORF plasmids Origene RC215640 Lentivirus vector pCDH-EF1-MCS-IRES-Puro System Biosciences CD532A-2
WNT5A-ROR2 axis mediates VEGF dependence of BRAF mutant melanoma
Coupe, Guo, Bridges et al
Cell Oncol (Dordr) (2022) 46 (2), 391-407 DOI: 10.1007/s13402-022-00757-7
Coupe, Guo, Bridges et al
Cell Oncol (Dordr) (2022) 46 (2), 391-407 DOI: 10.1007/s13402-022-00757-7
Cited by 7
AI Summary: In this study, the OriGene ROR2 overexpression plasmid (#RC215640) was used to investigate the role of ROR2 in VEGF secretion and tumor behavior in BRAF mutant melanoma cells.
Snippet: …ROR2 overexpression plasmid (#RC215640) was from Origene and empty vector pCMV6 (#PS100001) from James Chettle (Department of Oncology, University of Oxford, UK). Plasmid and siRNA transfection For siRNA transfection, cells were seeded to achieve 4;- ROR2 overexpression plasmid (#RC215640) was from Origene and empty vector pCMV6 (#PS100001) from James Chettle (Department of Oncology, University of Oxford,
ROR2 suppresses metastasis of prostate cancer via regulation of miR-199a-5p-PIAS3-AKT2 signaling axis
Tseng, Huang, Lin et al
Cell Death Dis (2020) 11 (5), 376 DOI: 10.1038/s41419-020-2587-9
Tseng, Huang, Lin et al
Cell Death Dis (2020) 11 (5), 376 DOI: 10.1038/s41419-020-2587-9
Cited by 39
AI Summary: OriGene products, specifically the qSTAR miRNA qPCR detection system and the pCMV-ROR2 (RC215640) plasmid, were used in this study to quantify miRNA expression and to overexpress ROR2 in prostate cancer cells, enabling investigation of ROR2's role in suppressing metastasis via the miR-199a-5p-PIAS3-AKT2 signaling axis.
Snippet: …Plasmids and siRNA Expression of ROR2-Flag plasmid (pCMV-ROR2, RC215640), hsa-miR-199;The total RNA was isolated by using the Qiagen RNeasy Mini kit (Qiagen, Venlo, Netherlands), and 2 μg complementary DNA was produced by the RevertAid H Minus First Strand cDNA kit (Thermo Fisher Scientific). …
Showing 1-3 of 3 papers.
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