CD130 (IL6ST) (NM_002184) Human Tagged ORF Clone
SKU
RC215123
IL6ST (Myc-DDK-tagged)-Human interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST), transcript variant 1
$840.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | CD130 |
| Synonyms | CD130; CDW130; GP130; HIES4; IL-6RB; sGP130 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_002184 |
| ORF Size | 2754 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_002184.4 |
| RefSeq Size | 3242 bp |
| RefSeq ORF | 2757 bp |
| Locus ID | 3572 |
| UniProt ID | P40189 |
| Cytogenetics | 5q11.2 |
| Domains | FN3 |
| Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
| Protein Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
| MW | 103.54 kDa |
| Summary | The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. provided by RefSeq, May 2014 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_002184" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC215123L1 | Lenti ORF clone of Human interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST), transcript variant 1, Myc-DDK-tagged | 10 ug |
$1,140.00
|
|
| RC215123L2 | Lenti ORF clone of Human interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST), transcript variant 1, mGFP tagged | 10 ug |
$1,140.00
|
|
| RC215123L3 | Lenti ORF clone of Human interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST), transcript variant 1, Myc-DDK-tagged | 10 ug |
$1,140.00
|
|
| RC215123L4 | Lenti ORF clone of Human interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST), transcript variant 1, mGFP tagged | 10 ug |
$1,140.00
|
|
| RG215123 | IL6ST (tGFP-tagged) - Human interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST), transcript variant 1 | 10 ug |
$789.00
$1,040.00
|
|
| SC111643 | IL6ST (untagged)-Human interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST), transcript variant 1 | 10 ug |
$841.00
|
|
Citations
A4gnt-Deficient Mice Show Enhanced IL-11 Receptor α- Glycoprotein 130-Janus Kinase 2-STAT3 Signaling in Early Stages of Gastric Tumorigenesis: Comparative Analysis with A4gnt and Il11 Doubly Deficient Mice
Harumiya, Maranan Desamero, Mikoshiba et al
Am J Pathol (2026)
Harumiya, Maranan Desamero, Mikoshiba et al
Am J Pathol (2026)
AI Summary: OriGene’s pCMV6-Entry-Myc-FLAG-gp130 (RC215123) plasmid was used in this study to overexpress gp130 in cell-based assays, enabling the investigation of how αGlcNAc modification affects IL-11-induced STAT3 signaling in gastric cancer cells.
Snippet: One sample (control) was transfected with 2 μg of pCMV6-Entry-Myc-FLAG-gp130 (RC215123;OriGene Technologies, Rockville, MD) together with 2 μg of empty pcDNAI vector [Thermo Fisher Scientific (Invitrogen), Waltham, MA], whereas the other sample was transfected with 2 μg of pCMV6-Entry-Myc-FLAG-gp130 together with 2 μg of pcDNAI-α4GnT.6 Following transfection, cells were diluted with Dulbecco's modified Eagle's medium supplemented with 10% heat-inactivated fetal
LIFR antagonism reverses epithelial pro-CAF programs in pancreatic ductal adenocarcinoma
Giorgio, Sette, Sensini et al
Biochem Pharmacol (2026) 246, 117707 DOI: 10.1016/j.bcp.2026.117707
Giorgio, Sette, Sensini et al
Biochem Pharmacol (2026) 246, 117707 DOI: 10.1016/j.bcp.2026.117707
Cited by 1
AI Summary: OriGene products, specifically the human LIFR plasmid (RC226327) and IL6ST/CD130 plasmid (RC215123), were used to transfect cells and assess LIFR-dependent STAT3 activation, thereby facilitating the study of LIF:LIFR axis signaling in pancreatic ductal adenocarcinoma.
Snippet: Extracellular matrix remodelling that occurs in pancreatic ductal adenocarcinoma (PDAC) is considered a promoting factor of cancer growth, immune evasion and;To evaluate LIFR-dependent STAT3 activation, HEPG2 cells were seeded into 24-well plates at 7.5 × 104 cells/well and incubated for 24 h. Cells were then co-transfected with plasmids encoding human LIFR (100 ng;OriGene RC226327), IL6ST/CD130 (100 ng;OriGene RC215123),
Exploring Boswellia serrata Triterpenes: A New Frontier in Leukemia Inhibitory Factor Receptor Modulation
Finamore, Festa, Cammarota et al
ACS Omega (2025) 10 (21), 22269-22284 DOI: 10.1021/acsomega.5c03492
Finamore, Festa, Cammarota et al
ACS Omega (2025) 10 (21), 22269-22284 DOI: 10.1021/acsomega.5c03492
Cited by 7
AI Summary: In this study, OriGene products hLIFR (CAT no. RC226327) and CD130 (IL6ST) (CAT no. RC215123) expression vectors were used to transiently transfect cells for functional assays investigating the inhibitory effects of Boswellia serrata triterpenes on leukemia inhibitory factor receptor (LIFR) signaling.
Snippet: … E4041 Promega, Madison, WI, USA), a vector encoding the hLIFR (CAT no. RC226327) and CD130 (IL6ST) (CAT no. RC215123, OriGene Technologies, Inc. …
Digenic impairments of haploinsufficient genes in patients with craniosynostosis
Yu, Yoon, Han et al
JCI Insight (2025) 10 (4) DOI: 10.1172/jci.insight.176985
Yu, Yoon, Han et al
JCI Insight (2025) 10 (4) DOI: 10.1172/jci.insight.176985
Cited by 2
Bile acids serve as endogenous antagonists of the Leukemia inhibitory factor (LIF) receptor in oncogenesis
Di Giorgio, Morretta, Lupia et al
Biochem Pharmacol (2024) 223, 116134 DOI: 10.1016/j.bcp.2024.116134
Di Giorgio, Morretta, Lupia et al
Biochem Pharmacol (2024) 223, 116134 DOI: 10.1016/j.bcp.2024.116134
Cited by 20
Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma
Di Giorgio, Lupia, Marchianò et al
Cells (2022) 11 (21) DOI: 10.3390/cells11213482
Di Giorgio, Lupia, Marchianò et al
Cells (2022) 11 (21) DOI: 10.3390/cells11213482
Cited by 17
AI Summary: OriGene products, specifically the hLIFR expression plasmid (CAT# RC226327) and the CD130 (IL6ST) expression plasmid (CAT# RC215123), were used to enable overexpression of LIFR and its co-receptor in cell-based assays investigating mifepristone's antagonistic effects on LIFR signaling in pancreatic cancer cells.
Snippet: d with the reporter plasmid pGL4.47[luc2P/SIE/Hygro] (200 ng) (CAT#: E4041 Promega, Madison, WI, USA), a vector encoding the hLIFR (CAT# RC226327) (100 ng) and CD130 (IL6ST) (100 ng) (CAT#: RC215123, OriGene Technologies, Inc. Rockville, MD, USA), and finally a vector encoding the human RENILLA luciferase gene (pGL4.70) (100 ng) (Promega, Madison, WI, USA). On day 2, cells were primed with the cyt
Showing 1-6 of 8 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
