CD130 (IL6ST) (NM_002184) Human Untagged Clone
SKU
SC111643
IL6ST (untagged)-Human interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST), transcript variant 1
$841.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | CD130 |
| Synonyms | CD130; CDW130; GP130; HIES4; IL-6RB; sGP130 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_002184 |
| Insert Size | 5500 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_002184.2, NP_002175.2 |
| RefSeq Size | 3242 bp |
| RefSeq ORF | 2757 bp |
| Locus ID | 3572 |
| UniProt ID | P40189 |
| Cytogenetics | 5q11.2 |
| Domains | FN3 |
| Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
| Protein Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
| Summary | The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. provided by RefSeq, May 2014 Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_002184" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC215123 | IL6ST (Myc-DDK-tagged)-Human interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST), transcript variant 1 | 10 ug |
$840.00
|
|
| RC215123L1 | Lenti ORF clone of Human interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST), transcript variant 1, Myc-DDK-tagged | 10 ug |
$1,140.00
|
|
| RC215123L2 | Lenti ORF clone of Human interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST), transcript variant 1, mGFP tagged | 10 ug |
$1,140.00
|
|
| RC215123L3 | Lenti ORF clone of Human interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST), transcript variant 1, Myc-DDK-tagged | 10 ug |
$1,140.00
|
|
| RC215123L4 | Lenti ORF clone of Human interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST), transcript variant 1, mGFP tagged | 10 ug |
$1,140.00
|
|
| RG215123 | IL6ST (tGFP-tagged) - Human interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST), transcript variant 1 | 10 ug |
$789.00
$1,040.00
|
|
Citations
Apratoxin a reversibly inhibits the secretory pathway by preventing cotranslational translocation
Liu, Law, Luesch
Mol Pharmacol (2009) 76 (1), 91-104 DOI: 10.1124/mol.109.056085
Liu, Law, Luesch
Mol Pharmacol (2009) 76 (1), 91-104 DOI: 10.1124/mol.109.056085
Cited by 148
AI Summary: In this paper, OriGene products—including the gp130 (IL6ST) and PDGFRB antibodies—were used to detect and analyze the down-regulation of key receptor proteins, helping to demonstrate that apratoxin A inhibits the secretory pathway by preventing cotranslational translocation.
Showing 1-1 of 1 papers.
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