THRAP3 (NM_005119) Human Tagged ORF Clone
$874.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | THRAP3 |
| Synonyms | BCLAF2; TRAP150 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_005119 |
| ORF Size | 2865 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_005119.4 |
| RefSeq Size | 4447 bp |
| RefSeq ORF | 2868 bp |
| Locus ID | 9967 |
| UniProt ID | Q9Y2W1 |
| Cytogenetics | 1p34.3 |
| Protein Families | Druggable Genome, Transcription Factors |
| MW | 108.7 kDa |
| Summary | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).UniProtKB/Swiss-Prot Function |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_005119" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC213342L1 | Lenti ORF clone of Human thyroid hormone receptor associated protein 3 (THRAP3), Myc-DDK-tagged | 10 ug |
$1,174.00
|
|
| RC213342L2 | Lenti ORF clone of Human thyroid hormone receptor associated protein 3 (THRAP3), mGFP tagged | 10 ug |
$1,174.00
|
|
| RC213342L3 | Lenti ORF clone of Human thyroid hormone receptor associated protein 3 (THRAP3), Myc-DDK-tagged | 10 ug |
$1,174.00
|
|
| RC213342L4 | Lenti ORF clone of Human thyroid hormone receptor associated protein 3 (THRAP3), mGFP tagged | 10 ug |
$1,174.00
|
|
| RG213342 | THRAP3 (tGFP-tagged) - Human thyroid hormone receptor associated protein 3 (THRAP3) | 10 ug |
$789.00
$1,074.00
|
|
| SC314985 | THRAP3 (untagged)-Human thyroid hormone receptor associated protein 3 (THRAP3) | 10 ug |
$963.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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