MLH3 (NM_014381) Human Tagged ORF Clone
$1,222.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | MLH3 |
| Synonyms | HNPCC7 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_014381 |
| ORF Size | 4287 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_014381.3 |
| RefSeq Size | 7839 bp |
| RefSeq ORF | 4290 bp |
| Locus ID | 27030 |
| UniProt ID | Q2M1Z1 |
| Cytogenetics | 14q24.3 |
| Domains | HATPase_c |
| Protein Families | Druggable Genome |
| Protein Pathways | Mismatch repair |
| MW | 161 kDa |
| Summary | This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. provided by RefSeq, Jul 2008 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_014381" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC212150L3 | Lenti ORF clone of Human mutL homolog 3 (E. coli) (MLH3), transcript variant 2, Myc-DDK-tagged | 10 ug |
$1,522.00
|
|
| RC212150L4 | Lenti ORF clone of Human mutL homolog 3 (E. coli) (MLH3), transcript variant 2, mGFP tagged | 10 ug |
$1,522.00
|
|
| RG212150 | MLH3 (tGFP-tagged) - Human mutL homolog 3 (E. coli) (MLH3), transcript variant 2 | 10 ug |
$789.00
$1,422.00
|
|
| SC127828 | MLH3 (untagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 2 | 10 ug |
$1,223.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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