CD226 (NM_006566) Human Tagged ORF Clone
$686.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | CD226 |
| Synonyms | DNAM-1; DNAM1; PTA1; TLiSA1 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_006566 |
| ORF Size | 1008 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_006566.1, NP_006557.1 |
| RefSeq Size | 2664 bp |
| RefSeq ORF | 1011 bp |
| Locus ID | 10666 |
| UniProt ID | Q15762 |
| Cytogenetics | 18q22.2 |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Cell adhesion molecules (CAMs) |
| MW | 38.6 kDa |
| Summary | This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jan 2015 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_006566" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC210437L1 | Lenti ORF clone of Human CD226 molecule (CD226), Myc-DDK-tagged | 10 ug |
$986.00
|
|
| RC210437L2 | Lenti ORF clone of Human CD226 molecule (CD226), mGFP tagged | 10 ug |
$986.00
|
|
| RC210437L3 | Lenti ORF clone of Human CD226 molecule (CD226), Myc-DDK-tagged | 10 ug |
$986.00
|
|
| RC210437L4 | Lenti ORF clone of Human CD226 molecule (CD226), mGFP tagged | 10 ug |
$986.00
|
|
| RG210437 | CD226 (tGFP-tagged) - Human CD226 molecule (CD226) | 10 ug |
$886.00
|
|
| SC303792 | CD226 (untagged)-Human CD226 molecule (CD226) | 10 ug |
$686.00
|
|
Citations
Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy
Weulersse, Asrir, Pichler et al
Immunity (2020) 53 (4), 824-839.e10 DOI: 10.1016/j.immuni.2020.09.006
Weulersse, Asrir, Pichler et al
Immunity (2020) 53 (4), 824-839.e10 DOI: 10.1016/j.immuni.2020.09.006
Cited by 141
AI Summary: OriGene contributed the CD226 (NM_006566) human tagged ORF clone (Cat#: RC210437), which was used in this study to investigate the role of CD226 in CD8+ T cell function and anti-tumor immunity.
Snippet: BaEV envelope plasmid (phcmv-g expression plasmid) Gift from E.Verhoyen Girard-Gagnepain et al., 2014 HF envelope plasmid Gift from E.Verhoyen Lévy et al., 2017 CD226 (NM_006566) human tagged ORF clone Origene Cat#: RC210437 pCMV-dR8.91 (gag-pol-rev) Gift from B.Couderc N/A Software and Algorithms
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
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in shipping.
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