MEF2D (NM_005920) Human Tagged ORF Clone
$485.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | MEF2D |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_005920 |
| ORF Size | 1563 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_005920.2, NP_005911.1 |
| RefSeq Size | 5996 bp |
| RefSeq ORF | 1566 bp |
| Locus ID | 4209 |
| UniProt ID | Q14814 |
| Cytogenetics | 1q22 |
| Protein Families | Transcription Factors |
| MW | 55.9 kDa |
| Summary | This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. provided by RefSeq, Oct 2012 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_005920" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC208748L3 | Lenti ORF clone of Human myocyte enhancer factor 2D (MEF2D), Myc-DDK-tagged | 10 ug |
$785.00
|
|
| RC208748L4 | Lenti ORF clone of Human myocyte enhancer factor 2D (MEF2D), mGFP tagged | 10 ug |
$785.00
|
|
| RG208748 | MEF2D (tGFP-tagged) - Human myocyte enhancer factor 2D (MEF2D) | 10 ug |
$489.00
$685.00
|
|
| SC323859 | MEF2D (untagged)-Human myocyte enhancer factor 2D (MEF2D) | 10 ug |
$486.00
|
|
Citations
DYRK1A phosphorylates MEF2D and decreases its transcriptional activity
Wang, Zhao, Sun
J Cell Mol Med (2021) 25 (13), 6082-6093 DOI: 10.1111/jcmm.16505
Wang, Zhao, Sun
J Cell Mol Med (2021) 25 (13), 6082-6093 DOI: 10.1111/jcmm.16505
Cited by 14
AI Summary: OriGene products, specifically the DYRK1A (RC209832) and MEF2D (RC222889) expression plasmids, were used in this study to investigate the interaction and functional effects of DYRK1A-mediated phosphorylation on MEF2D's transcriptional activity.
Mef2d sustains activation of effector Foxp3+ Tregs during transplant survival and anticancer immunity
Di Giorgio, Wang, Xiong et al
J. Clin. Invest. (2020)
Di Giorgio, Wang, Xiong et al
J. Clin. Invest. (2020)
Dual-specificity tyrosine-phosphorylation regulated kinase 1A Gene Transcription is regulated by Myocyte Enhancer Factor 2D
Wang, Wang, Chen et al
Sci Rep (2017) 7 (1), 7240 DOI: 10.1038/s41598-017-07655-1
Wang, Wang, Chen et al
Sci Rep (2017) 7 (1), 7240 DOI: 10.1038/s41598-017-07655-1
AI Summary: OriGene products pCMV6-entry-MEF2D (RC208748) and pCMV6-entry-DYRK1A (RC213183) expression constructs were used to investigate the regulatory relationship between MEF2D and DYRK1A gene transcription in this study.
Snippet: pCMV6-entry-MEF2D construct (RC208748, Origene Co., Beijing, China);pCMV6-entry-DYRK1A construct (RC213183, Origene Co., Beijing, China);NFATc2 expression vector (#11100, Addgene, Cambridge, MA, USA);pGL3-basic vector (E1751, Promega, Madison ... All 3 versions Cite SaveSaving
Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia
Liu, Wang, Zhang et al
EBioMedicine (2016)
Liu, Wang, Zhang et al
EBioMedicine (2016)
Cited by 1
Showing 1-4 of 4 papers.
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