TYRO3 (NM_006293) Human Tagged ORF Clone
$1,222.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | TYRO3 |
| Synonyms | BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_006293 |
| ORF Size | 2670 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_006293.4 |
| RefSeq Size | 3949 bp |
| RefSeq ORF | 2673 bp |
| Locus ID | 7301 |
| UniProt ID | Q06418 |
| Cytogenetics | 15q15.1 |
| Protein Families | Druggable Genome, Protein Kinase |
| MW | 96.7 kDa |
| Summary | The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. provided by RefSeq, May 2010 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_006293" in other vectors (7)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC208260L1 | Lenti ORF clone of Human TYRO3 protein tyrosine kinase (TYRO3), Myc-DDK-tagged | 10 ug |
$1,522.00
|
|
| RC208260L2 | Lenti ORF clone of Human TYRO3 protein tyrosine kinase (TYRO3), mGFP tagged | 10 ug |
$1,522.00
|
|
| RC208260L3 | Lenti ORF clone of Human TYRO3 protein tyrosine kinase (TYRO3), Myc-DDK-tagged | 10 ug |
$1,522.00
|
|
| RC208260L4 | Lenti ORF clone of Human TYRO3 protein tyrosine kinase (TYRO3), mGFP tagged | 10 ug |
$1,522.00
|
|
| RC600075 | TYRO3 (DDK-His-tagged)-Extra Cellular Domain Clone of Homo sapiens TYRO3 protein tyrosine kinase, Signal peptide (1-40) plus EC domain (41-429) | 10 ug |
$686.00
|
|
| RG208260 | TYRO3 (tGFP-tagged) - Human TYRO3 protein tyrosine kinase (TYRO3) | 10 ug |
$1,422.00
|
|
| SC108283 | TYRO3 (untagged)-Human TYRO3 protein tyrosine kinase (TYRO3) | 10 ug |
$1,223.00
|
|
Citations
Tyro3 Targeting as a Radiosensitizing Strategy in Bladder Cancer through Cell Cycle Dysregulation
Silina, Dufour, Rapinat et al
Int J Mol Sci (2022) 23 (15) DOI: 10.3390/ijms23158671
Silina, Dufour, Rapinat et al
Int J Mol Sci (2022) 23 (15) DOI: 10.3390/ijms23158671
Cited by 5
AI Summary: In this study, OriGene’s Tyro3 Human shRNA Plasmid Kit (cat# TG313764) and Tyro3 Human cDNA ORF Clone (cat# RC221328) were used to modulate TYRO3 expression in bladder cancer cell models, enabling the investigation of TYRO3’s role in radiosensitization and cell cycle regulation.
TYRO3 facilitates cell growth and metastasis via activation of the Wnt/β-catenin signaling pathway in human gastric cancer cells
Chen, Liu, Cao et al
Aging (Albany NY) (2020) 12 (3), 2261-2274 DOI: 10.18632/aging.102744
Chen, Liu, Cao et al
Aging (Albany NY) (2020) 12 (3), 2261-2274 DOI: 10.18632/aging.102744
Cited by 16
AI Summary: OriGene products, specifically the TYRO3 cDNA clone (Cat# RC218438) and TYRO3 shRNA plasmids (Cat# TG312527), were used to overexpress and silence TYRO3 in gastric cancer cells, enabling the authors to study TYRO3's role in promoting cell growth and metastasis via the Wnt/β-catenin signaling pathway.
The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells
Paolino, Choidas, Wallner et al
Nature (2014)
Paolino, Choidas, Wallner et al
Nature (2014)
Cited by 459
Showing 1-3 of 3 papers.
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