SLC22A6 (NM_153276) Human Tagged ORF Clone
SKU
RC207579
SLC22A6 (Myc-DDK-tagged)-Human solute carrier family 22 (organic anion transporter), member 6 (SLC22A6), transcript variant 2
$768.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | SLC22A6 |
| Synonyms | HOAT1; OAT1; PAHT; ROAT1 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_153276 |
| ORF Size | 1650 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_153276.3 |
| RefSeq Size | 2220 bp |
| RefSeq ORF | 1653 bp |
| Locus ID | 9356 |
| UniProt ID | Q4U2R8 |
| Cytogenetics | 11q12.3 |
| Protein Families | Transmembrane |
| MW | 60.3 kDa |
| Summary | The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. provided by RefSeq, Jul 2008 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_153276" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC207579L1 | Lenti ORF clone of Human solute carrier family 22 (organic anion transporter), member 6 (SLC22A6), transcript variant 2, Myc-DDK-tagged | 10 ug |
$1,068.00
|
|
| RC207579L2 | Lenti ORF clone of Human solute carrier family 22 (organic anion transporter), member 6 (SLC22A6), transcript variant 2, mGFP tagged | 10 ug |
$1,068.00
|
|
| RC207579L3 | Lenti ORF clone of Human solute carrier family 22 (organic anion transporter), member 6 (SLC22A6), transcript variant 2, Myc-DDK-tagged | 10 ug |
$1,068.00
|
|
| RC207579L4 | Lenti ORF clone of Human solute carrier family 22 (organic anion transporter), member 6 (SLC22A6), transcript variant 2, mGFP tagged | 10 ug |
$1,068.00
|
|
| RG207579 | SLC22A6 (tGFP-tagged) - Human solute carrier family 22 (organic anion transporter), member 6 (SLC22A6), transcript variant 2 | 10 ug |
$968.00
|
|
| SC123302 | SLC22A6 (untagged)-Human solute carrier family 22 (organic anion transporter), member 6 (SLC22A6), transcript variant 2 | 10 ug |
$820.00
|
|
Citations
Estrone sulphate uptake by the microvillous membrane of placental syncytiotrophoblast is coupled to glutamate efflux
Lofthouse, Cleal, O'Kelly et al
Biochem. Biophys. Res. Commun. (2018)
Lofthouse, Cleal, O'Kelly et al
Biochem. Biophys. Res. Commun. (2018)
Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity
Hu, Leblanc, Gibson et al
Clin Transl Sci (2017)
Hu, Leblanc, Gibson et al
Clin Transl Sci (2017)
AI Summary: OriGene products, specifically full-length human OCT2, OAT1, OAT3, and mouse Oat1/Oat3 cDNA clones, were used to assess transporter function and elucidate the role of OAT1/OAT3 in cisplatin-induced nephrotoxicity in this study.
Snippet: Assessment of transporter function Full-length human OCT2, OAT1/OAT3, and mouse Oat1/Oat3 were obtained from Origene (Rockville, MD). Fusion-flag fragments were amplified by high-fidelity polymerase chain reaction (PCR). ... All 2 versions Cite SaveSaving
Stronger Uricosuric Effects of the Novel Selective URAT1 Inhibitor UR-1102 Lowered Plasma Urate in Tufted Capuchin Monkeys to a Greater Extent than Benzbromarone
Ahn, Ohtomo, Kiyokawa et al
J. Pharmacol. Exp. Ther. (2016) 357 (1), 157-66 DOI: 10.1124/jpet.115.231647
Ahn, Ohtomo, Kiyokawa et al
J. Pharmacol. Exp. Ther. (2016) 357 (1), 157-66 DOI: 10.1124/jpet.115.231647
Cited by 62
Sex-, Species-, and Tissue-Specific Metabolism of Empagliflozin in Male Mouse Kidney Forms an Unstable Hemiacetal Metabolite (M466/2) That Degrades to 4-Hydroxycrotonaldehyde, a Reactive and Cytotoxic Species
Taub, Ludwig-Schwellinger, Ishiguro et al
Chem. Res. Toxicol. (2015)
Taub, Ludwig-Schwellinger, Ishiguro et al
Chem. Res. Toxicol. (2015)
Cited by 34
AI Summary: OriGene contributed to this study by providing plasmid vectors (pCMV6-ENTRY) containing cDNA for various transporters—including oat1, oat3, oct1, oct2, oatp1a1, sglt1, and sglt2—which were used to investigate empagliflozin transport in transfected HEK293 cells.
Snippet: commercial suppliers. Plasmid vectors (pCMV6-ENTRY) containing cDNA for target transporters (oat1, oat3, oct1, oct2, oatp1a1, sglt1and sglt2) were obtained from Origene (Rockville, MD, USA). The plasmid vector, pSPORT1, containing either Oct1 or Oct2 were ... Cite SaveSaving
The involvement of selected membrane transport mechanisms in the cellular uptake of 177Lu-labeled bombesin, somatostatin and gastrin analogues
Volková, Mandíková, Lázníčková
Nuclear Medicine and Biology (2014)
Volková, Mandíková, Lázníčková
Nuclear Medicine and Biology (2014)
AI Summary: OriGene products contributed to this study by providing the pCMV6-Entry vector (GenBank accession number: PS100001), which was used as an empty vector control in the transfection experiments to analyze the role of specific renal transporters in the cellular uptake of radiolabeled peptides.
Snippet: manufacturer. The cells transiently transfected with empty vector (pCMV6-Entry vector, genebank accession number: PS100001) served as the control. All plasmids were obtained from OriGene Technologies (Rockville, USA). Twenty ... Cite SaveSaving
The renal handling of amphotericin B and amphotericin B/deoxycholate and potential renal drug-drug interactions with selected antivirals
Trejtnar, Mandíková, Kočíncová et al
Antimicrob. Agents Chemother. (2014)
Trejtnar, Mandíková, Kočíncová et al
Antimicrob. Agents Chemother. (2014)
AI Summary: OriGene products, specifically the human OAT1 (SLC22A6) expression plasmid (RC207579), human OCT2 (SLC22A2) expression plasmid (RC207921), and the pCMV6-Entry vector (PS100001), were used to transiently transfect HeLa and MDCK II cells for studying the role of renal transporters in the excretion and drug-drug interactions of amphotericin B and its prodrug.
Showing 1-6 of 6 papers.
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