NALP12 (NLRP12) (NM_144687) Human Tagged ORF Clone
SKU
RC207045
NLRP12 (Myc-DDK-tagged)-Human NLR family, pyrin domain containing 12 (NLRP12), transcript variant 2
$924.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | NALP12 |
| Synonyms | CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-RsrII Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_144687 |
| ORF Size | 3183 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_144687.4 |
| RefSeq Size | 3880 bp |
| RefSeq ORF | 3186 bp |
| Locus ID | 91662 |
| UniProt ID | P59046 |
| Cytogenetics | 19q13.42 |
| Domains | LRR, PAAD_DAPIN |
| MW | 120.2 kDa |
| Summary | This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. provided by RefSeq, Mar 2013 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_144687" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC207045L1 | Lenti ORF clone of Human NLR family, pyrin domain containing 12 (NLRP12), transcript variant 2, Myc-DDK-tagged | 10 ug |
$1,224.00
|
|
| RC207045L2 | Lenti ORF clone of Human NLR family, pyrin domain containing 12 (NLRP12), transcript variant 2, mGFP tagged | 10 ug |
$1,224.00
|
|
| RC207045L3 | Lenti ORF clone of Human NLR family, pyrin domain containing 12 (NLRP12), transcript variant 2, Myc-DDK-tagged | 10 ug |
$1,224.00
|
|
| RC207045L4 | Lenti ORF clone of Human NLR family, pyrin domain containing 12 (NLRP12), transcript variant 2, mGFP tagged | 10 ug |
$1,224.00
|
|
| RG207045 | NLRP12 (tGFP-tagged) - Human NLR family, pyrin domain containing 12 (NLRP12), transcript variant 2 | 10 ug |
$789.00
$1,124.00
|
|
| SC124283 | NLRP12 (untagged)-Human NLR family, pyrin domain containing 12 (NLRP12), transcript variant 2 | 10 ug |
$924.00
|
|
Citations
Persistent DNA damage-induced NLRP12 improves hematopoietic stem cell function
Lin, Wu, Ma et al
JCI Insight (2020) 5 (10) DOI: 10.1172/jci.insight.133365
Lin, Wu, Ma et al
JCI Insight (2020) 5 (10) DOI: 10.1172/jci.insight.133365
Cited by 10
AI Summary: In this study, OriGene products—including the NLRP12 shRNA (TL506669), NLRP12 cDNA clone (RC220317), and NLRP12 antibody (TA500644)—were used to manipulate and detect NLRP12 expression, enabling the authors to elucidate its role in improving hematopoietic stem cell function under persistent DNA damage.
Snippet: (27) and has been considered a negative regulator of the canonical and noncanonical pathways of NF-κB (28). In fact, NLRP12-mediated NF-κB suppression was implicated in colonic inflammation and tumorigenesis and osteoclast differentiation (29). Studies using the _Nlrp12-_knockout mouse model reveal a critical role for NLRP12 in maintaining intestinal homeostasis and providing protection against
Showing 1-1 of 1 papers.
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