Plexin A4 (PLXNA4) (NM_181775) Human Tagged ORF Clone
$486.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | Plexin A4 |
| Synonyms | FAYV2820; PLEXA4; PLXNA4A; PLXNA4B; PRO34003 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_181775 |
| ORF Size | 1566 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_181775.2, NP_861440.1 |
| RefSeq Size | 2020 bp |
| RefSeq ORF | 1569 bp |
| Locus ID | 91584 |
| UniProt ID | Q9HCM2 |
| Cytogenetics | 7q32.3 |
| Protein Families | Druggable Genome |
| MW | 58.1 kDa |
| Summary | Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).UniProtKB/Swiss-Prot Function |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_181775" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC206375L1 | Lenti ORF clone of Human plexin A4 (PLXNA4), transcript variant 2, Myc-DDK-tagged | 10 ug |
$786.00
|
|
| RC206375L2 | Lenti ORF clone of Human plexin A4 (PLXNA4), transcript variant 2, mGFP tagged | 10 ug |
$786.00
|
|
| RC206375L3 | Lenti ORF clone of Human plexin A4 (PLXNA4), transcript variant 2, Myc-DDK-tagged | 10 ug |
$786.00
|
|
| RC206375L4 | Lenti ORF clone of Human plexin A4 (PLXNA4), transcript variant 2, mGFP tagged | 10 ug |
$786.00
|
|
| RG206375 | PLXNA4 (tGFP-tagged) - Human plexin A4 (PLXNA4), transcript variant 2 | 10 ug |
$489.00
$686.00
|
|
| SC107330 | PLXNA4 (untagged)-Human plexin A4 (PLXNA4), transcript variant 2 | 10 ug |
$487.00
|
|
Citations
Plexin-A4 mediates amyloid-β-induced tau pathology in Alzheimer's disease animal model
Chung, Yang, Kim et al
Prog Neurobiol (2021) 203, 102075 DOI: 10.1016/j.pneurobio.2021.102075
Chung, Yang, Kim et al
Prog Neurobiol (2021) 203, 102075 DOI: 10.1016/j.pneurobio.2021.102075
Cited by 19
AI Summary: OriGene contributed human plexin-A4 isoform plasmids (TS1, TS2, and TS3 in pCMV6-Entry vector with C-terminal Myc and DDK tags), which were used to study the role of plexin-A4 in amyloid-β-induced tau pathology in Alzheimer's disease models.
Snippet: …Human plexin-A4 isoforms TS1, TS2, and TS3 encoded in pCMV6-Entry (C-terminal Myc and DDK tagged) vector were purchased from Origene (Rockville, MD);Human plexin-A4 isoforms TS1, TS2, and TS3 encoded in pCMV6-Entry (C-terminal Myc and DDK tagged) vector were purchased from Origene (Rockville, MD)
PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation
Jun, Asai, Zeldich et al
Ann. Neurol. (2014)
Jun, Asai, Zeldich et al
Ann. Neurol. (2014)
Cited by 68
AI Summary: OriGene's PLXNA4 isoform expression plasmids (TS1, TS2, and TS3) were used to transfect cells, enabling the study of isoform-specific effects on tau phosphorylation relevant to Alzheimer’s disease pathogenesis.
Snippet: The cells were transfected with empty vector (EV) or PLXNA4 isoforms (TS1, TS2, or TS3) from OriGene using Attractene (Qiagen, Valencia, CA). Forty-eight hours post-transfection, media were collected and cells were lysed as described.[28]. ... Cite SaveSaving
Showing 1-2 of 2 papers.
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