SOCS5 (NM_144949) Human Tagged ORF Clone
SKU
RC206267
SOCS5 (Myc-DDK-tagged)-Human suppressor of cytokine signaling 5 (SOCS5), transcript variant 2
$499.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | SOCS5 |
| Synonyms | CIS6; Cish5; CISH6; SOCS-5 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_144949 |
| ORF Size | 1608 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_144949.3 |
| RefSeq Size | 4510 bp |
| RefSeq ORF | 1611 bp |
| Locus ID | 9655 |
| UniProt ID | O75159 |
| Cytogenetics | 2p21 |
| Domains | SH2, SOCS |
| Protein Families | Druggable Genome |
| Protein Pathways | Jak-STAT signaling pathway |
| MW | 61.2 kDa |
| Summary | The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. provided by RefSeq, Jul 2008 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_144949" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC206267L3 | Lenti ORF clone of Human suppressor of cytokine signaling 5 (SOCS5), transcript variant 2, Myc-DDK-tagged | 10 ug |
$799.00
|
|
| RC206267L4 | Lenti ORF clone of Human suppressor of cytokine signaling 5 (SOCS5), transcript variant 2, mGFP tagged | 10 ug |
$799.00
|
|
| RG206267 | SOCS5 (tGFP-tagged) - Human suppressor of cytokine signaling 5 (SOCS5), transcript variant 2 | 10 ug |
$489.00
$699.00
|
|
| SC124288 | SOCS5 (untagged)-Human suppressor of cytokine signaling 5 (SOCS5), transcript variant 2 | 10 ug |
$500.00
|
|
Citations
The genetic effect and molecular function of the SOCS5 in the prognosis of esophageal squamous cell carcinoma
Yang, Chang, Wong et al
J Cancer (2021) 12 (8), 2216-2229 DOI: 10.7150/jca.51806
Yang, Chang, Wong et al
J Cancer (2021) 12 (8), 2216-2229 DOI: 10.7150/jca.51806
Cited by 5
AI Summary: OriGene products, including the SOCS5 cDNA clone and SOCS5-specific shRNA lentiviral particles, were used in this study to manipulate SOCS5 expression in esophageal squamous cell carcinoma cells, enabling the authors to investigate the gene’s role in tumor progression and prognosis.
The genetic effect and molecular function of the SOCS5 in the prognosis of esophageal squamous cell carcinoma
Yang, Chang, Wong et al
Journal of … (2021) 12 (8), 2216-2229 DOI: 10.7150/jca.51806
Yang, Chang, Wong et al
Journal of … (2021) 12 (8), 2216-2229 DOI: 10.7150/jca.51806
Cited by 5
AI Summary: OriGene products contributed to this study by providing the myc-DDK-tagged SOCS5/pCMV6 expression plasmid (RC206267) and TurboFect transfection reagent, which were used to investigate the molecular function of SOCS5 in esophageal squamous cell carcinoma cells.
Snippet: … The myc-DDK-tagged SOCS5/pCMV6 (myc-SOCS5/pCMV6) expression plasmids were purchased from OriGene Technologies (RC206267) Mien-Chie Hung 35 , using TurboFect (Origene) according to manufacturer's instructions;- Plasmid construction The myc-DDK-tagged SOCS5/pCMV6 (myc-SOCS5/pCMV6) expression plasmids were purchased from OriGene Technologies (RC206267) Mien-Chie Hung [35], using TurboFect (Origene) according to manufacturer's instructions
Showing 1-2 of 2 papers.
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