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MS4A4A (NM_148975) Human Tagged Lenti ORF Clone

  • LentiORF®
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SKU
RC204646L1
Lenti ORF clone of Human membrane-spanning 4-domains, subfamily A, member 4 (MS4A4A), transcript variant 2, Myc-DDK-tagged
ORF Plasmid:
DDK DDK tGFP
Lentiviral Particles:
DDK mGFP DDK w/ Puro mGFP w/ Puro
AAV Particle:
DDK
  $600.00
In Stock*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone
Target Symbol MS4A4A
Synonyms 4SPAN1; CD20-L1; CD20L1; HDCME31P; MS4A4; MS4A7
Vector pLenti-C-Myc-DDK
E. coli Selection Chloramphenicol (34 ug/mL)
Mammalian Cell Selection None
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC204646).
Restriction Sites SgfI-MluI Cloning Scheme for this gene | Plasmid Map
ACCN NM_148975
ORF Size 717 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_148975.1
RefSeq Size 1668 bp
RefSeq ORF 720 bp
Locus ID 51338
UniProt ID Q96JQ5
Cytogenetics 11q12.2
Protein Families Druggable Genome, Transmembrane
MW 25.4 kDa
Summary This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features, similar intron/exon splice boundaries, and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Aug 2011
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"NM_148975" in other vectors (7)
SKU Description Size Price
RC204646 MS4A4A (Myc-DDK-tagged)-Human membrane-spanning 4-domains, subfamily A, member 4 (MS4A4A), transcript variant 2 10 ug
$300.00
RC204646L2 Lenti ORF clone of Human membrane-spanning 4-domains, subfamily A, member 4 (MS4A4A), transcript variant 2, mGFP tagged 10 ug
$600.00
RC204646L3 Lenti ORF clone of Human membrane-spanning 4-domains, subfamily A, member 4 (MS4A4A), transcript variant 2, Myc-DDK-tagged 10 ug
$600.00
RC204646L4 Lenti ORF clone of Human membrane-spanning 4-domains, subfamily A, member 4 (MS4A4A), transcript variant 2, mGFP tagged 10 ug
$600.00
RG204646 MS4A4A (tGFP-tagged) - Human membrane-spanning 4-domains, subfamily A, member 4 (MS4A4A), transcript variant 2 10 ug
$489.00 $500.00
SC306347 MS4A4A (untagged)-Human membrane-spanning 4-domains, subfamily A, member 4 (MS4A4A), transcript variant 2 10 ug
$300.00
SC321118 MS4A4A (untagged)-Human membrane-spanning 4-domains, subfamily A, member 4 (MS4A4A), transcript variant 2 10 ug
$300.00

Plasmid Map for RC204646L1

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Cloning scheme for RC204646L1
Circular map for RC204646L1

file-alt Citations

MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state
You, Brase, Filipello et al
medRxiv (2023)
Cited by 27
AI Summary: OriGene products, specifically the lentiviral vectors encoding GFP (PS100071) and human MS4A4A WT in Myc-DDK-tagged vector (RC204646L1), were used to manipulate gene expression in cell models to investigate the functional effects of MS4A4A on microglial states relevant to Alzheimer’s disease risk.
Snippet: … Lentiviral vectors encoding GFP (PS100071) and human MS4A4A WT (NM_148975) in Myc-DDK-tagged vector (RC204646L1) were obtained from OriGene. …Cultured monocyte-derived macrophages w;- Lentiviral vectors encoding GFP (PS100071) and human MS4A4A WT (NM_148975) in Myc-DDK-tagged vector (RC204646L1) were obtained from OriGene. …
FigureFigureFigure
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk
Deming, Filipello, Cignarella et al
Sci Transl Med (2019) 11 (505) DOI: 10.1126/scitranslmed.aau2291
Cited by 286
AI Summary: OriGene products, including the MS4A4A cDNA clone (RC208442) and TREM2 cDNA clone (RC218590), were used in this study to overexpress MS4A4A and TREM2 in human macrophages, enabling the authors to investigate how these genes modulate soluble TREM2 levels and contribute to Alzheimer's disease risk.
FigureFigure
Showing 1-2 of 2 papers.
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