SNX2 (NM_003100) Human Tagged ORF Clone
$483.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | SNX2 |
| Synonyms | TRG-9 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_003100 |
| ORF Size | 1557 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_003100.4 |
| RefSeq Size | 6559 bp |
| RefSeq ORF | 1560 bp |
| Locus ID | 6643 |
| UniProt ID | O60749 |
| Cytogenetics | 5q23.2 |
| Domains | PX, Sorting_nexin |
| MW | 58.5 kDa |
| Summary | This gene belongs to the sorting nexin family whose members contain the phosphoinositide-binding phox (PX) domain. The encoded protein is a component of the retromer complex which plays a role in protein sorting in the endocytic pathway. This protein may form oligomeric complexes with other family members. Alternate splicing results in multiple transcript variants of this gene. Pseudogenes associated with this gene are located on chromosomes 1 and 7. provided by RefSeq, May 2013 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_003100" in other vectors (5)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC201621L3 | Lenti ORF clone of Human sorting nexin 2 (SNX2), Myc-DDK-tagged | 10 ug |
$783.00
|
|
| RC201621L4 | Lenti ORF clone of Human sorting nexin 2 (SNX2), mGFP tagged | 10 ug |
$783.00
|
|
| RG201621 | SNX2 (tGFP-tagged) - Human sorting nexin 2 (SNX2) | 10 ug |
$489.00
$683.00
|
|
| SC118155 | SNX2 (untagged)-Human sorting nexin 2 (SNX2) | 10 ug |
$484.00
|
|
| SC322180 | SNX2 (untagged)-Human sorting nexin 2 (SNX2) | 10 ug |
$484.00
|
|
Citations
Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling
Duclos, Champagne, Carrier et al
Cell Death Discov (2017) 3, 16100 DOI: 10.1038/cddiscovery.2016.100
Duclos, Champagne, Carrier et al
Cell Death Discov (2017) 3, 16100 DOI: 10.1038/cddiscovery.2016.100
Cited by 19
AI Summary: OriGene products, specifically the SNX2 shRNA (OriGene, TL313781) and SNX2 cDNA plasmid (OriGene, RC210285), were used in this study to knock down and re-express SNX2 in cells, enabling the authors to investigate the functional consequences of SNX2 depletion and rescue on retromer assembly and Met/HGF receptor signaling.
Showing 1-1 of 1 papers.
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