CD70 (NM_001252) Human Tagged ORF Clone
$300.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | CD70 |
| Synonyms | CD27-L; CD27L; CD27LG; LPFS3; TNFSF7; TNLG8A |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_001252 |
| ORF Size | 579 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_001252.5 |
| RefSeq Size | 913 bp |
| RefSeq ORF | 582 bp |
| Locus ID | 970 |
| UniProt ID | P32970 |
| Cytogenetics | 19p13.3 |
| Protein Families | ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Cytokine-cytokine receptor interaction |
| MW | 21.1 kDa |
| Summary | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. provided by RefSeq, Jul 2008 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_001252" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC200410L1 | Lenti ORF clone of Human CD70 molecule (CD70), Myc-DDK-tagged | 10 ug |
$600.00
|
|
| RC200410L2 | Lenti ORF clone of Human CD70 molecule (CD70), mGFP tagged | 10 ug |
$600.00
|
|
| RC200410L3 | Lenti ORF clone of Human CD70 molecule (CD70), Myc-DDK-tagged | 10 ug |
$600.00
|
|
| RC200410L4 | Lenti ORF clone of Human CD70 molecule (CD70), mGFP tagged | 10 ug |
$600.00
|
|
| RG200410 | CD70 (tGFP-tagged) - Human CD70 molecule (CD70) | 10 ug |
$489.00
$500.00
|
|
| SC122587 | CD70 (untagged)-Human CD70 molecule (CD70) | 10 ug |
$300.00
|
|
Citations
Single amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2α phosphorylation and thereby downregulates IgG secretion despite operational secretory pathway traffic
Hasegawa, Hsu, Tinberg et al
MAbs (2017)
Hasegawa, Hsu, Tinberg et al
MAbs (2017)
Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency
Abolhassani, Edwards, Ikinciogullari et al
J. Exp. Med. (2017) 214 (1), 91-106 DOI: 10.1084/jem.20160849
Abolhassani, Edwards, Ikinciogullari et al
J. Exp. Med. (2017) 214 (1), 91-106 DOI: 10.1084/jem.20160849
Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab
Ramakrishna, Sundarapandiyan, Zhao
Journal for ImmunoTherapy of Cancer (2015) 3, 37
Ramakrishna, Sundarapandiyan, Zhao
Journal for ImmunoTherapy of Cancer (2015) 3, 37
Showing 1-3 of 3 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
