Slc22a6 (NM_008766) Mouse Tagged ORF Clone
- TrueORF®
SKU
MR208683
Slc22a6 (Myc-DDK-tagged) - Mouse solute carrier family 22 (organic anion transporter), member 6 (Slc22a6)
$289.00
$508.00
In Stock*
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
|---|---|
| Target Symbol | Slc22a6 |
| Synonyms | mOat1; NKT; Oat1; Orctl1 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_008766 |
| ORF Size | 1635 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_008766.3 |
| RefSeq Size | 4026 bp |
| RefSeq ORF | 1638 bp |
| Locus ID | 18399 |
| UniProt ID | Q8VC69 |
| Cytogenetics | 19 5.44 cM |
| MW | 60 kDa |
| Summary | Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) and edaravone sulfate (By similarity). Mediates the sodium-independent uptake of p-aminohippurate (PAH). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, bumetamide, losartan, probenecid, phenol red, urate, glutarate and alpha-ketoglutarate (By similarity). PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), indomethacin, sulindac, diclofenac, carprofen, okadaic acid and PKC activators.UniProtKB/Swiss-Prot Function |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_008766" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| MC200825 | Slc22a6 (untagged) - Mouse solute carrier family 22 (organic anion transporter), member 6 (Slc22a6), (10ug) | 10 ug |
$508.00
|
|
| MG208683 | Slc22a6 (tGFP-tagged) - Mouse solute carrier family 22 (organic anion transporter), member 6 (Slc22a6) | 10 ug |
$708.00
|
|
| MR208683L3 | Lenti ORF clone of Slc22a6 (Myc-DDK-tagged) - Mouse solute carrier family 22 (organic anion transporter), member 6 (Slc22a6) | 10 ug |
$808.00
|
|
| MR208683L4 | Lenti ORF clone of Slc22a6 (mGFP-tagged) - Mouse solute carrier family 22 (organic anion transporter), member 6 (Slc22a6) | 10 ug |
$808.00
|
|
Citations
Sex-, Species-, and Tissue-Specific Metabolism of Empagliflozin in Male Mouse Kidney Forms an Unstable Hemiacetal Metabolite (M466/2) That Degrades to 4-Hydroxycrotonaldehyde, a Reactive and Cytotoxic Species
Taub, Ludwig-Schwellinger, Ishiguro et al
Chem. Res. Toxicol. (2015)
Taub, Ludwig-Schwellinger, Ishiguro et al
Chem. Res. Toxicol. (2015)
Cited by 34
AI Summary: OriGene contributed to this study by providing plasmid vectors (pCMV6-ENTRY) containing cDNA for various transporters—including oat1, oat3, oct1, oct2, oatp1a1, sglt1, and sglt2—which were used to investigate empagliflozin transport in transfected HEK293 cells.
Snippet: commercial suppliers. Plasmid vectors (pCMV6-ENTRY) containing cDNA for target transporters (oat1, oat3, oct1, oct2, oatp1a1, sglt1and sglt2) were obtained from Origene (Rockville, MD, USA). The plasmid vector, pSPORT1, containing either Oct1 or Oct2 were ... Cite SaveSaving
Showing 1-1 of 1 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
