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Exd2 (NM_133798) Mouse Tagged ORF Clone

  • TrueORF®
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SKU
MR207967
Exd2 (Myc-DDK-tagged) - Mouse exonuclease 3'-5' domain containing 2 (Exd2)
Interest in protein/lysate? Submit request here!
ORF Plasmid:
DDK tGFP
Lentiviral Particles:
DDK w/ Puro mGFP w/ Puro
AAV Particle:
DDK
$289.00 $457.00
In Stock*
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Other products for "Exd2 or NM_133798"

Specifications
Specifications
Product Data
Type Mouse Tagged ORF Clone
Target Symbol Exd2
Synonyms 4930539P14Rik; C85658; Exdl2
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
ORF Nucleotide Sequence
>MR207967 ORF sequence
Red=Cloning site Blue=ORF Green=Tags(s)

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGGCTTCCCCAAGTGGCTTCTGTGCACTGGTTCGCTTGCCCAGGCTGATATATGGAGGCAGAACACTAC
CCAGGACGCTTTTGGATATATTGGCAGATGGTGCTATCTTAAAAGTAGGAGTGGGATGTTCAGAAGATGC
CAACAAGCTTCTACAGGATTATGGTCTCATTGTCAGGGGATGTCTGGACCTTCGCTACCTAGCCATGAAG
CAGGGAAACAATATACTCTGTAATGGGCTTAGCCTGAAATCACTTGCTGAGACTATTTTGAACTTCCCAC
TTGACAAGTCCCTTCTACTTCGTTGCAGCAACTGGGATGCTGAGAATCTTACTGAAGACCAGGTAACTTA
TGCTGCCAGGGATGCGCAGATTTCAGTGGCTCTCTTTCTCCATCTTCTTGGATACCCTTTCTCTAGAGAT
TCCTATGAAGAGGAAAGTACGGACCAAATCAACTGGCAAAAAGCCTTGGAGAGATGCAGGAATATGGTAG
ACATCCCATTCCGAAGCAAAGGACTTGGCCGGCTGGTTGAAGAGGTTAATGGGGAAGCACTGGAGTCGCA
GCTGAAGCCGAGAAATAGGAAGGCTAAGACTGATAGAATGGTGCCAGGCAACAACCAAGGGAGAGACCCC
AGGAAGCATAAGAGGAAGCCCCTGGGGGTGGGCTATTCTGCCAGAAAATCCCCTCTCTATGATAACTGCT
TCCTCCAAGCTCCTGATGGACAGCCCTTGTGCACCTGTGACCGCAGGAAAGCTCAGTGGTACCTGGACAA
AGGCATTGGAGAGCTGGTGAGTAAAGAACCTTTTGTGGTCAGGCTACAGTTTGAACCTGCAGGAAGACCT
GAGTCCCCAGGAGATTATTACTTGATGGTTAAAGAGAATCTGTGTGTTGTCTGTGGCAAGACAGATACCT
ACATCCGGAAAAATATAATTCCACATGAGTACCGCAAGCATTTCCCTATTGAGATGAAGGACCACAACTC
CCATGATGTGCTGTTGCTCTGCACCTCCTGCCATGCCATCTCTAACTACTATGACAACCATCTGAAGCAA
CAGCTGGCCAAGGAGTTCCAGGCTCCCATTGGCTCAGAGGAGGGCCTACGCCTGCTGGAAGACTTAGAGC
GGAGACAGGTGCGTTCTGGAGCCAGAGCCCTGCTCAACGCAGAGAGCCTACCTGCTCATCGGAAAGAAGA
GCTGCTGCACGCACTCAGGGAGTTTTACAACACAGATATTATTACAGAGGAGATGCTTCACGAGGCCGCC
AGCCTGGAGACCAGGATATACAATGAAAGTTATATTCCTCATGGGCTAAAGGTGGTACAGCGTCACACCG
AGGGTGGGCTGCGCTCCCTCATGCAGCTGGAGAGCCGCTGGCGTCAGCACTTCCTGGACTCCATGCAGCC
TAAGCACCTGCCCCAGCAGTGGTCAGTGGACCACAACCATCAGAAGCTGCTCCGAAAGTACGGGGATGAC
CTTCCCATCAAGCTGTCA

ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
Protein Sequence
>MR207967 protein sequence
Red=Cloning site Green=Tags(s)

MASPSGFCALVRLPRLIYGGRTLPRTLLDILADGAILKVGVGCSEDANKLLQDYGLIVRGCLDLRYLAMK
QGNNILCNGLSLKSLAETILNFPLDKSLLLRCSNWDAENLTEDQVTYAARDAQISVALFLHLLGYPFSRD
SYEEESTDQINWQKALERCRNMVDIPFRSKGLGRLVEEVNGEALESQLKPRNRKAKTDRMVPGNNQGRDP
RKHKRKPLGVGYSARKSPLYDNCFLQAPDGQPLCTCDRRKAQWYLDKGIGELVSKEPFVVRLQFEPAGRP
ESPGDYYLMVKENLCVVCGKTDTYIRKNIIPHEYRKHFPIEMKDHNSHDVLLLCTSCHAISNYYDNHLKQ
QLAKEFQAPIGSEEGLRLLEDLERRQVRSGARALLNAESLPAHRKEELLHALREFYNTDIITEEMLHEAA
SLETRIYNESYIPHGLKVVQRHTEGGLRSLMQLESRWRQHFLDSMQPKHLPQQWSVDHNHQKLLRKYGDD
LPIKLS

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Restriction Sites SgfI-MluI Cloning Scheme for this gene | Plasmid Map
ACCN NM_133798
ORF Size 1488 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_133798.3
RefSeq Size 3323 bp
RefSeq ORF 1953 bp
Locus ID 97827
UniProt ID Q8VEG4
Cytogenetics 12 C3
MW 56.8 kDa
Summary Exonuclease required for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks.UniProtKB/Swiss-Prot Function
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Documents
Resources
"NM_133798" in other vectors (4)
SKU Description Size Price
MC203864 Exd2 (untagged) - Mouse exonuclease 3'-5' domain containing 2 (Exd2), (10ug) 10 ug
$503.00
MG207967 Exd2 (tGFP-tagged) - Mouse exonuclease 3''-5'' domain-like 2 (Exdl2) 10 ug
$657.00
MR207967L3 Lenti ORF clone of Exd2 (Myc-DDK-tagged) - Mouse exonuclease 3'-5' domain containing 2 (Exd2) 10 ug
$757.00
MR207967L4 Lenti ORF clone of Exd2 (mGFP-tagged) - Mouse exonuclease 3'-5' domain containing 2 (Exd2) 10 ug
$757.00

Plasmid Map for MR207967

Download sequence for

file-download TXT (FASTA format)

file-download Genbank

Cloning scheme for MR207967
Circular map for MR207967

file-alt Citations

Intermitochondrial cement (IMC) harbors piRNA biogenesis machinery and exonuclease domain-containing proteins EXD1 and EXD2 in mouse spermatocytes
Olotu, Dowling, Homolka et al
Andrology (2023) 11 (4), 710-723 DOI: 10.1111/andr.13361
Cited by 13
AI Summary: In this study, OriGene products, specifically the EXD1 (Cat# MR207993) and EXD2 (Cat# MR209663) cDNA clones, were used to characterize the expression and localization of these proteins in mouse spermatocytes, aiding in the investigation of their roles in piRNA biogenesis within the intermitochondrial cement (IMC).
Showing 1-1 of 1 papers.
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