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Kank2 (NM_145611) Mouse Tagged ORF Clone

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SKU
MG216907
Kank2 (tGFP-tagged) - Mouse KN motif and ankyrin repeat domains 2 (Kank2), (10ug)
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ORF Plasmid:
tGFP DDK
  $972.00
3 Weeks*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Mouse Tagged ORF Clone
Target Symbol Kank2
Synonyms AI504612; Ankrd25; BC010245
Vector pCMV6-AC-GFP
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
ORF Nucleotide Sequence
>MG216907 representing NM_145611
Red=Cloning site Blue=ORF Green=Tags(s)

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGGCCCAGGTCCTGCATGTGCCCGCCCCATTCCCAGGAACCCCTGGTCAGGCCTCCCCAGCGGCCTTCC
CCAGCAAGGAGCCAGACCCACCGTACTCAGTGGAAACGCCCTATGGCTACCGCCTGGACCTGGATTTTCT
TAAGTACGTGGATGACATTGAGAAGGGCCACACACTGCGCAGGGTGGCGGTACAGCGCCGGCCGCGCCTG
GGTTCCCTGCCACGGGGCCCGGGCTCCTGGTGGACGTCCACAGAGTCTCTGTGCTCTGATGCCAGTGGGG
ACAGCCGGCACTCGGCCTACTCCTACTGTGGCCGCGGCTTCTACCCACAGTACGGAGCCTTGGAGACCCG
AATCGGCTCCAACCCTCGTGTGGAGCGCACGCTGCTGGATGCGCGGCGCCGGCTGGAGGACCAGGCGGCT
GCCCCATCGTCCGGTGGCCTGGGCTCCCTCACACCCAGCGCCGCGGGCTCCACCAGCTCCCTGGCAGGCG
TGGGCCTGCTGCCCCCCACGCCTCGCAGCTCCGGCCTGTCCACCCCGGTGGCACCCAGCGCTGGTCACCT
AGCCCACGTGCGCGAGCAGATGGCTGGAGCCCTGCGCAAGCTGCGCCAGCTGGAGGAGCAGGTCAAGCTG
ATCCCCGTTCTCCAAGTCAAGCTGTCAGTGCTCCAGGAGGAAAAGAGACAGCTCACCGTGCAGCTCAAGA
GCCAGAAGTTTCTAGGTCACCCCTCAGGGACACGGAGCCGGAGTGAGCTCTGCCTGGACCTTCCCGAGGC
CCCTGACGACCCTGCTGCACTAGAGACCCGCTCGGTGGGCACCTGGGTTAGAGAACGGGACTTGGGCATT
CCAGATGGTGAAGCTGCCCTGGTAGCTAAAGTGGCCGTGTTGGAGACCCAGCTCAAAAAAGCGCTACAGG
AGCTGCGGGCGGCTCAGACCCAGCAGGTCGACCTCCAGCCCCAGGCCTGGCCACCACCAGACACCCAGGT
CCGCGTGGACACCGTGCGAGTAGTGGAGGGTCCCCGGGAAGTGGAGGTGGCAGCCAGCACGGCAGCCGGG
GCCCTTGCACAGCGAGCTCAGAGTCTGGAACCCTACGGAACAGGGCTGAAGGCCCTGACCACATCTGGGG
GACCAGAGAACACCCTCGTGTTCCGCAGTCATGAAGTGGTGGAGACCATGTGCCCACTGCCCACAGCTAC
CACTGGCAATGTGCACACAGCCAAGAAGATCAGCATTACAGAACGGAGTTGCACCGGTGCACCCAGGATG
ACAGAGCCTTCCTCCGTTAATCCACGCCCTGCTGCAGCCTCTGTGGTACAGCCTGAGAACCCTGTCCCGG
CTGCCCAGGACACCACTGACAAGAAGCCCACCAGGCCAGCAGCAGCATCGCAGGACTCACAAGCGGCTGA
CGGAGCAGGCAGAGCCTCTTTGGCCACGAAGAGGAAAGAGGACCCCGCAGACCCTGAAGTCAACCAGAGG
AACCTCCAGTTTGTGGGAGTCAATGGCGGGTATGAGTCCCCCTCGGAGGACTCCAGCACAGCAGAAAACT
CCGAACACGAGAGCACAGAGAACGAGGGCCCGGAGCCACCAGCAAGGGTTCTGAGCCCAGCTGAATGTCC
TCAGCTCAGGCCTCCAGGGGCTGCAGTGGCCACGACCAGTCTGGAGGGGCCCCAGCTCTCCCAGGAATCC
CAGCGTGTGCCTGCACCTGAGGTGGCGTCAGGACCCGATCCTGAGGAGGAAATTCGGATGGATCTGAGCC
CTGACCTCATATCAGCCTGCTTGGCCCTGGAGAAATACCTGGAGAACCCCAATGCCCTCACAGAGCGAGA
ACTGAAAGTGGCCTATACCACAGTGCTTCAGGAGTGGCTGCGCCTGGCCTGCCGCAGTGACGCACACCCT
GAGCTTGTGCGGCGACATCTAGTCACCTTCAGGGCCATGTCTGCCCGGCTGCTGGACTACGTGGTCAACA
TCGCCGACAGCAATGGTAACACTGCCCTGCACTACTCAGTGTCACACGCCAACTTCCCTGTGGTGCGGCA
GTTGCTGGACAGCGGGGTCTGTCATGTGGACAAGCTGAACCGTGCCGGCTACAGCCCTATTATGCTCACT
GCCCTGGCCACGTTGAAGACCCAGGACGACATTGAGACCATCCTTCAGCTCTTCCGGCTTGGGAATGTCA
ATGCCAAAGCCAGCCAGGCAGGACAGACGGCCCTGATGCTGGCCGTCAGCCACGGGCGGGTGGACGTGGT
GAGAGCATTGCTGGCCTGTGAGGCGGACGTCAACATTCAGGATGAGGACGGCTCCACGGCCCTGATGTGT
GCATGTGAGCACGGACACAAGGAGATCACCGGGCTCCTGCTGGCTGTGCCTAGCTGTGACATCTCACTCA
CTGACCGCGACGGGAGCACAGCACTGATGGTGGCCCTGGACGCTGGGCAGAGCGAGATCGCATCTATGCT
GTACTCACGCATGAACATCAAGTGCTCGTTCGCTCCCATGTCAGACTACGAGAGTCCGGCTTCGTCTTCA
GCCGAGGAG

ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA
Protein Sequence
>MG216907 representing NM_145611
Red=Cloning site Green=Tags(s)

MAQVLHVPAPFPGTPGQASPAAFPSKEPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPRL
GSLPRGPGSWWTSTESLCSDASGDSRHSAYSYCGRGFYPQYGALETRIGSNPRVERTLLDARRRLEDQAA
APSSGGLGSLTPSAAGSTSSLAGVGLLPPTPRSSGLSTPVAPSAGHLAHVREQMAGALRKLRQLEEQVKL
IPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPSGTRSRSELCLDLPEAPDDPAALETRSVGTWVRERDLGI
PDGEAALVAKVAVLETQLKKALQELRAAQTQQVDLQPQAWPPPDTQVRVDTVRVVEGPREVEVAASTAAG
ALAQRAQSLEPYGTGLKALTTSGGPENTLVFRSHEVVETMCPLPTATTGNVHTAKKISITERSCTGAPRM
TEPSSVNPRPAAASVVQPENPVPAAQDTTDKKPTRPAAASQDSQAADGAGRASLATKRKEDPADPEVNQR
NLQFVGVNGGYESPSEDSSTAENSEHESTENEGPEPPARVLSPAECPQLRPPGAAVATTSLEGPQLSQES
QRVPAPEVASGPDPEEEIRMDLSPDLISACLALEKYLENPNALTERELKVAYTTVLQEWLRLACRSDAHP
ELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVRQLLDSGVCHVDKLNRAGYSPIMLT
ALATLKTQDDIETILQLFRLGNVNAKASQAGQTALMLAVSHGRVDVVRALLACEADVNIQDEDGSTALMC
ACEHGHKEITGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSDYESPASSS
AEE

TRTRPLE - GFP Tag - V
Restriction Sites SgfI-MluI Cloning Scheme for this gene | Plasmid Map
ACCN NM_145611
ORF Size 2529 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_145611.4, NP_663586.3
RefSeq Size 4853 bp
RefSeq ORF 2532 bp
Locus ID 235041
UniProt ID Q8BX02
Cytogenetics 9 A3
Summary Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (By similarity). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (By similarity). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (By similarity). Involved in the negative control of vitamin D receptor signaling pathway (By similarity). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (PubMed:16024821).UniProtKB/Swiss-Prot Function
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Documents
Resources
"NM_145611" in other vectors (4)
SKU Description Size Price
MC222025 Kank2 (untagged) - Mouse KN motif and ankyrin repeat domains 2 (Kank2), (10ug) 10 ug
$850.00
MR216907 Kank2 (Myc-DDK-tagged) - Mouse KN motif and ankyrin repeat domains 2 (Kank2) 10 ug
$589.00 $772.00
MR216907L3 Lenti ORF clone of Kank2 (Myc-DDK-tagged) - Mouse KN motif and ankyrin repeat domains 2 (Kank2) 10 ug
$1,072.00
MR216907L4 Lenti ORF clone of Kank2 (mGFP-tagged) - Mouse KN motif and ankyrin repeat domains 2 (Kank2) 10 ug
$1,072.00

file-alt Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.