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Larp1 (NM_028451) Mouse Untagged Clone

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SKU
MC223454
Larp1 (untagged) - Mouse La ribonucleoprotein domain family, member 1 (Larp1), (10ug)
Interest in protein/lysate? Submit request here!
ORF Plasmid:
Tag Free tGFP DDK
  $1,027.00
7 Weeks*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Mouse Untagged Clone
Target Symbol Larp1
Synonyms 1810024J12Rik; 3110040D16Rik; Larp; mKIAA0731
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>MC223454 representing NM_028451
Red=Cloning site Blue=ORF Orange=Stop codon

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGGCCACTCAAGTGGAGCCGCTGCTGCCGGCGGGCGCCCCGCTGCTGCAGGCCGAGGAGCACGGCCTGG
CGAGGAAGAAGCCGGCGCCCGACGCCCAGGCCGAGTCGGGCCCGGGTGACGGCGGCGGAGAGCCCGACGG
CGGCGTCCGCAGGCCGCGGCCCGCCTGCGCCAGGCCTGGCCGCGACGGCGCGGAGCGCGAGAGCCCGCGG
CCACCCGCAGCTGCGGAAGCCCCAGCGGGGAGCGACGGCGAGGACGGCGGCCGGCGTGACTTCGTGGAGG
CACCGCCGCCCAAGGTGAACCCGTGGACGAAGCACGCGCCGCCGCCGGCCGCGGTGAACGGACAGCCGCC
TCCAGAACCTTCTGCTCCAGCCAAGGTGGTGAGGGCAGCTGCTCCTAAACCGCGTAAGGGCAGCAAGGTT
GGTGATTTTGGAGATGCAGTCAACTGGCCTACACCTGGAGAGATAGCCCACAAAAGTGTGCAGCCACAGT
CCCACAAGCCTCAGCCTGCTCGTAAGTTGCCACCTAAGAAGGACATGAAGGAGCAAGAGAAAGGAGATGG
AAGTGATAGTAAGGAGAGCCCAAAAACAAAGTCGGATGAATCGGGGGAGGAAAAGAATGGGGATGAGGAC
TGCCAGCGAGGCGGGCAGAAGAAGAAAGGGAGCAAACACAAGTGGGTTCCATTGCAAATAGACATGAAGC
CCGAAGTACCCAGAGAGAAATTGGCCTCCCGTCCCACTCGCCCACAGGAACCAAGACATACACCCGCTGT
CCGTGGGGAGATGAAAGGATCTGAACCTGCCACCTACATGCCTGTATCTGTGGCCCCACCCACCCCAGCC
TGGCAACCAGAGACCAAAGTGGAGCCTGCCTGGCACGACCAGGATGAGACATCGAGTGTGAAGAGTGATG
GGGCTGGTGGGGCTCGGGCTTCCTTCCGTGGCCGTGGACGGGGGCGTGGTCGTGGACGGGGCCGTGGACG
GGGTGGCACTCGAACCCACTTTGACTACCAGTTTGGCTACCGAAAGTTTGATGGTACAGAGGGGCCCCGC
ACCCACAAGTATATGAACAACATCACTTACTACTTTGACAATGTCAGCAGCAATGAGATTTACAGTATGG
ACCAGGAGCTGCTCAAGGATTATATCAAACGCCAGATTGAATATTACTTCAGCGTGGACAATTTAGAGCG
AGACTTCTTCCTGAGACGGAAAATGGATGCTGATGGCTTCCTTCCCATCACCCTTATTGCTTCCTTTCAC
CGTGTACAGGCCCTAACCACTGACATTTCACTCATCTTTGCGGCTCTAAAGGACAGCAAGGTGGTAGAGA
TGGTTGAGGAGAAAGTCCGCAGGAGGGAAGAACCTGAAAAGTGGCCACTGCCTGGACCCCCAATAGTGGA
TTATTCACAAACTGATTTTTCTCAGCTTCTCAACTGCCCAGAGTTTGTTCCCCGCCAGCACTACCAGAAA
GAGACAGAGTCGGCACCTGGCTCTCCCCGTGCAGTCACCCCAGTGCCAACAAAAACAGAGGAGGTCAGCA
ACCTGAAGACCCTTCCCAAGGGCCTGTCTGCCAGCCTCCCAGATCTGGATTCTGAGAGCTGGATTGAAGT
GAAGAAAAGGCCTCGACCCTCACCAGCACGCCCCAAGAAGCCAGAGGAGCCCAGGTTCTCCCACCCAACT
GCTCTGCCTCAGCAGCTTCCCTCCCAGCAGCTGATGTCTAAGGATCAGGATGAGCAAGAAGAACTAGACT
TTCTGTTTGACGAGGAGATGGAGCAGATGGATGGGCGGAAGAATACCTTCACTGCCTGGTCTGAAGAGGA
CTCTGACTATGAAATTGATGACCGGGATGTCAATAAGATCCTCATCGTCACTCAAACACCACCTTACATG
CGTCGCCACCCTGGAGGAGACCGTACAGGCAACCACACTTCGCGTGCCAAGATGAGTGCTGAACTGGCCA
AGGTCATTAATGATGGACTCTTCTACTATGAACAAGACCTGTGGACTGAGAAGTTTGAGCCTGAGTATTC
ACAGATCAAGCAAGAAGTGGAAAACTTCAAGAAAGTGAATATGATTAGTCGGGAACAGTTTGACACTCTG
ACCCCTGAGCCCCCTGTGGATCCTAACCAGGAGGTTCCTCCTGGGCCACCTCGGTTCCAACAAGTTCCTA
CTGATGCCCTGGCCAACAAGCTGTTTGGTGCTCCCGAGCCATCTACCATTGCCCGTTCTCTACCAACCAC
TGTCCCAGAGTCTCCAAACTACCGAAATGCCAGGACTCCCCGCACACCCCGGACCCCCCAGCTCAAAGAC
TCTAGTCAGACACCACGGTTTTACCCTGTGGTGAAAGAAGGACGGACCCTAGATGCCAAGATGCCTCGAA
AAAGAAAGACAAGGCACAGCTCGAACCCCCCCTTGGAAAGTCATGTGGGCTGGGTGATGGATTCTCGGGA
GCACAGGCCCAGGACTGCTTCTATTAGCTCCAGTCCTTCAGAGGGAACACCTGCAGTCGGCAGCTATGGC
TGTACCCCTCAGTCACTGCCCAAGTTCCAGCATCCTTCCCATGAGCTGCTCAAGGAAAATGGCTTCACAC
AACACGTCTACCACAAGTATCGGAGGCGCTGCCTTAATGAGCGGAAGCGCTTGGGCATTGGCCAGTCTCA
GGAGATGAACACCCTCTTCCGCTTTTGGTCCTTCTTCCTCCGAGATCACTTCAATAAAAAGATGTATGAA
GAGTTCAAGCAGCTCGCACTGGAGGATGCCAAAGAAGGCTACAGGTACGGTTTGGAGTGCCTTTTTCGAT
ACTACAGTTATGGTCTAGAGAAAAAGTTCCGGCTGGACATATTCAAGGATTTCCAGGAGGAGACAGTGAA
GGACTATGAGGCTGGCCAGCTCTATGGATTGGAGAAGTTCTGGGCCTTCTTGAAATACTCCAAAGCCAAA
AATTTGGACATTGACCCCAAACTGCAAGAATACCTCGGCAAATTCCGCCGCTTAGAAGACTTCCGAGTGG
ACCCCCCCATGGGCGAGGAAGGCAACCACAAGCGACACCCAGTGGTAGCAGGAGGCAGCGGAGAGGGCAG
GAAGCGGTGCCCTTCCCAGTCTTCCAGCAGGCCTGCCACTGGGATCAGCCAACCCCCTACGACACCTACT
GGCCAGGCCACTCGAGAAGATGCCAAATGGACAAGCCAGCACTCGGACACACTGACTTTGCGAAAGTGA

ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites SgfI-MluI |
ACCN NM_028451
Insert Size 3219 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_028451.1, NP_082727.1
RefSeq Size 6617 bp
RefSeq ORF 3219 bp
Locus ID 73158
UniProt ID Q6ZQ58
Cytogenetics 11 B1.3
Summary RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability. Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery. The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1. When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA. Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif. Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes. Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis. Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation. Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis.UniProtKB/Swiss-Prot Function
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"NM_028451" in other vectors (4)
SKU Description Size Price
MG224022 Larp1 (tGFP-tagged) - Mouse La ribonucleoprotein domain family member 1 (Larp1), (10ug). Note: ORF is codon optimized 10 ug
$1,133.00
MR224022 Larp1 (Myc-DDK-tagged) - Mouse La ribonucleoprotein domain family, member 1 (Larp1). Note: ORF is codon optimized 10 ug
$589.00 $933.00
MR224022L3 Lenti ORF clone of Larp1 (Myc-DDK-tagged) - Mouse La ribonucleoprotein domain family, member 1 (Larp1). Note: ORF is codon optimized 10 ug
$1,233.00
MR224022L4 Lenti ORF clone of Larp1 (mGFP-tagged) - Mouse La ribonucleoprotein domain family, member 1 (Larp1). Note: ORF is codon optimized 10 ug
$1,233.00

file-alt Citations

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