Olfm2 (NM_173777) Mouse Untagged Clone
$503.00
3 Weeks*
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
|---|---|
| Target Symbol | Olfm2 |
| Synonyms | A030009A06Rik |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites | SgfI-MluI | |
| ACCN | NM_173777 |
| Insert Size | 1347 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_173777.3, NP_776138.2 |
| RefSeq Size | 1525 bp |
| RefSeq ORF | 1347 bp |
| Locus ID | 244723 |
| UniProt ID | Q8BM13 |
| Cytogenetics | 9 A3 |
| Summary | Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation (By similarity). TGF-beta induces expression and nuclear translocation of OLFM2 where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (By similarity). Plays a role in AMPAR complex organization (PubMed:25218043). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity).UniProtKB/Swiss-Prot Function Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1. |
Reviews
Documents
| Product Manuals |
| FAQs |
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Resources
"NM_173777" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| MG220561 | Olfm2 (tGFP-tagged) - Mouse olfactomedin 2 (Olfm2), (10ug) | 10 ug |
$657.00
|
|
| MR220561 | Olfm2 (Myc-DDK-tagged) - Mouse olfactomedin 2 (Olfm2) | 10 ug |
$289.00
$457.00
|
|
| MR220561L3 | Lenti ORF clone of Olfm2 (Myc-DDK-tagged) - Mouse olfactomedin 2 (Olfm2) | 10 ug |
$757.00
|
|
| MR220561L4 | Lenti ORF clone of Olfm2 (mGFP-tagged) - Mouse olfactomedin 2 (Olfm2) | 10 ug |
$757.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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