Sip1 (BC053424) Mouse Untagged Clone
SKU
MC207094
Sip1 (untagged) - Mouse survivor of motor neuron protein interacting protein 1 (cDNA clone MGC:59266 IMAGE:6336522), (10ug)
$330.00
3 Weeks*
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
|---|---|
| Target Symbol | Sip1 |
| Synonyms | Gemin2 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites | SgfI-MluI | |
| ACCN | BC053424 |
| Insert Size | 537 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | BC053424, AAH53424 |
| RefSeq Size | 2064 bp |
| RefSeq ORF | 536 bp |
| Locus ID | 66603 |
| Cytogenetics | 12 C1 |
| Summary | This gene encodes one of the proteins found in the survival of motor neuron (SMN) complex, which consists of the SMN protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal small nuclear ribonucleoproteins (snRNP) and for pre-mRNA splicing. This protein interacts directly with the SMN protein and it is required for formation of the SMN complex. Disruption of this gene in mouse resulted in impaired snRNP assembly, and motor neuron degeneration. provided by RefSeq, Sep 2015 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"BC053424" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| MG201583 | Sip1 (tGFP-tagged) - Mouse survivor of motor neuron protein interacting protein 1 (cDNA clone MGC:59266 IMAGE:6336522) | 10 ug |
$500.00
|
|
| MR201583 | Sip1 (Myc-DDK-tagged) - Mouse survivor of motor neuron protein interacting protein 1 (cDNA clone MGC:59266 IMAGE:6336522) | 10 ug |
$289.00
$300.00
|
|
| MR201583L3 | Lenti ORF clone of Sip1 (Myc-DDK-tagged) - Mouse survivor of motor neuron protein interacting protein 1 (cDNA clone MGC:59266 IMAGE:6336522) | 10 ug |
$600.00
|
|
| MR201583L4 | Lenti ORF clone of Sip1 (mGFP-tagged) - Mouse survivor of motor neuron protein interacting protein 1 (cDNA clone MGC:59266 IMAGE:6336522) | 10 ug |
$600.00
|
|
Citations
BMP and TGF-β pathway mediators are critical upstream regulators of Wnt signaling during midbrain dopamine differentiation in human pluripotent stem cells
Cai, Schleidt, Pelta-Heller et al
Dev. Biol. (2013) 376 (1), 62-73 DOI: 10.1016/j.ydbio.2013.01.012
Cai, Schleidt, Pelta-Heller et al
Dev. Biol. (2013) 376 (1), 62-73 DOI: 10.1016/j.ydbio.2013.01.012
Cited by 45
AI Summary: In this study, OriGene’s SIP1 shRNA (catalog # TG310539) and Sfrp1 shRNA (catalog # TG310839) were used to knock down SIP1 and Sfrp1 expression, respectively, enabling the authors to demonstrate the regulatory roles of these genes in Wnt signaling and midbrain dopamine neuron differentiation from human pluripotent stem cells.
SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation
Acun, Oztas, Yagci et al
BMC Cancer (2011) 11, 223 DOI: 10.1186/1471-2407-11-223
Acun, Oztas, Yagci et al
BMC Cancer (2011) 11, 223 DOI: 10.1186/1471-2407-11-223
Cited by 34
AI Summary: OriGene’s TissueScan Liver Cancer Tissue qPCR Panel I was used in this study to analyze SIP1 expression across a range of liver cancer and normal tissue samples, enabling the authors to assess SIP1 downregulation in hepatocellular carcinoma.
Snippet: TissueScan Liver Cancer Tissue qPCR Panel I was purchased from Origene Technologies (Rockville, MD). ... A more detailed information on the samples can be found on the website below. http://www.origene.com/assets/documents/TissueScan/LVRT-01.xls webcite.
Showing 1-2 of 2 papers.
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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