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Mfn2 (NM_133201) Mouse Untagged Clone

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SKU
MC205980
Mfn2 (untagged) - Mouse mitofusin 2 (Mfn2), nuclear gene encoding mitochondrial protein, (10ug)
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ORF Plasmid:
Tag Free tGFP DDK
AAV Particle:
DDK
  $694.00
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Specifications
Specifications
Product Data
Type Mouse Untagged Clone
Target Symbol Mfn2
Synonyms D630023P19Rik; Fzo
Vector PCMV6-Kan/Neo
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>BC046503
GATGGCCGCCGCGAGGCCGGGAAGGTGAAGAAGCTTGGACAGGTGGAGTCAACACCATCAGGGGCCAACC TGGACCTGAATCAGCACAGAGGAGACCTCGAGTCCTTTTCATCTTTCTGACTCCAGCCATGTCCACGATG CCCAACCTGTGAAGGTCTCTTACCAGCTAGAAACGAGATGTCCCTGCTCTTTTCTCGATGCAACTCCATC GTCACCGTCAAGAAGGATAAGCGACACATGGCTGAAGTGAATGCTTCCCCTCTCAAGCACTTTGTCACTG CCAAGAAAAAGATCAATGGAATCTTTGAGCAGCTGGGGGCCTACATCCAAGAGAGCGCCAGCTTCCTTGA AGACACCCACAGGAACACAGAACTGGACCCGGTTACCACGGAAGAGCAGGTCCTGGACGTCAAAGGGTAC CTGTCCAAGGTCAGGGGTATCAGCGAAGTGCTGGCCAGGCGGCACATGAAGGTGGCTTTTTTTGGCCGGA CGAGCAATGGGAAGAGCACCGTGATCAATGCCATGCTCTGGGACAAAGTTCTGCTATCTGGGATTGGTCA TACCACCAATTGCTTCCTGCGGGTTGGGGGCACAGATGGCCATGAGGCCTTCCTCCTCACAGAGGGCTCA GAAGAGAAGAAGAGTGTCAAGACTGTGAACCAACTGGCCCATGCCCTCCATCAGGACGAGCAGTTGCATG CAGGCAGCATGGTGAGTGTGATGTGGCCCAACTCCAAGTGTCCGCTCCTGAAGGATGACCTCGTGCTGAT GGACAGCCCTGGGATCGATGTTACCACGGAGCTGGACAGCTGGATTGATAAGTTTTGCCTGGATGCTGAT GTGTTTGTGCTGGTGGCCAACTCAGAGTCCACGCTGATGCAGACGGAGAAGCAGTTCTTCCACAAAGTGA GTGAACGTCTCTCCCGGCCCAACATCTTCATCCTGAACAACCGCTGGGATGCGTCTGCCTCGGAGCCTGA GTACATGGAGGAGGTGCGGCGGCAGCACATGGAGCGCTGCACCAGCTTTCTGGTGGATGAGCTGGGCGTG GTGGATCGAGCTCAGGCTGGGGACCGGATCTTCTTCGTGTCTGCCAAGGAGGTTCTCAGCGCCAGGGTCC AGAAAGCCCAGGGCATGCCAGAAGGAGGCGGCGCTCTCGCAGAAGGTTTTCAAGTGAGGATGTTTGAGTT TCAGAATTTCGAGAGGCAGTTTGAGGAGTGCATTTCCCAGTCTGCAGTAAAGACCAAATTTGAGCAGCAC ACAGTCCGGGCCAAGCAGATTGCAGAGGCCGTTCGTCTCATCATGGATTCCCTGCACATCGCAGCTCAGG AGCAGCGGGTTTATTGCCTAGAAATGCGGGAAGAGCGGCAAGACCGGCTGAGGTTTATTGACAAGCAGCT GGAGCTCCTGGCTCAAGACTACAAGCTGCGAATTAAGCAGATTACGGAGGAAGTGGAAAGGCAGGTGTCC ACAGCCATGGCTGAAGAGATCAGGCGCCTCTCTGTGCTAGTTGACGAGTACCAGATGGACTTCCACCCAT CCCCAGTTGTCCTCAAGGTTTATAAGAACGAGCTGCACCGCCATATAGAGGAAGGTCTGGGCCGGAACCT GTCTGACCGCTGCTCCACTGCCATTGCCAGTTCACTGCAGACTATGCAGCAGGACATGATAGACGGCTTG AAGCCCCTTCTTCCTGTATCTATGCGGAATCAGATAGACATGCTGGTCCCTCGACAGTGTTTCTCCCTCA GCTATGACCTGAATTGTGACAAGCTGTGTGCTGACTTTCAGGAGGACATCGAGTTCCACTTCTCCCTTGG ATGGACTATGCTAGTGAACAGGTTCCTGGGCCCCAAGAATAGCCGCCGGGCCTTGCTAGGCTACAGTGAT CAGGTTCAGCGTCCTCTCCCTCTGACACCTGCCAACCCCAGCATGCCCCCCTTGCCACAGAGCTCCCTCA CCCAGGAGGAGCTCATGGTCTCCATGGTTACTGGCCTGGCCTCTCTGACGTCTAGGACCTCCATGGGCAT TCTTGTGGTCGGAGGAGTGGTGTGGAAGGCAGTGGGCTGGAGACTCATCGCCCTCTCCTTTGGACTGTAT GGCCTCCTGTACGTCTATGAGCGACTGACCTGGACCACCAAAGCCAAAGAGAGGGCCTTCAAGCGCCAGT TTGTGGAATACGCCAGTGAGAAGCTACAGCTCATCATCAGTTACACCGGCTCTAACTGCAGCCACCAAGT CCAGCAGGAATTGTCTGGGACATTTGCTCATCTGTGCCAGCAAGTTGACATCACCCGAGATAATCTGGAG CAGGAAATTGCTGCCATGAACAAGAAAGTCGAGGCTCTGGATTCACTTCAGAGCAGAGCCAAACTGCTCA GGAATAAAGCTGGCTGGTTGGACAGCGAACTCAACATGTTCACACACCAGTACCTGCAGCCCAGCAGATA GTGGGCAGCCAGGGCGGACCTGCACGAAGAAGAGGCAGGGCCGCACCTCCCATCAGCTCTAGTCCTTGGC CGCTGCAGAGAGAAGGAAAGCACCCAGTCTTGTACCAGTTACTCCCTACCCCCTGCAGGAAGACCCCTGG CTCATACCCTAATGGAGACCAACAAGGACTGGACAGCTCGGCTCCAAGGAGTTATGCATGTGTCTGTGTC TGCTCCTCACGCTCACCCGGTTGAAAGTCACTGTGCATTTGATAAAGTTTTCCTCAGAATGGCACCCTGC AGAATGACTGATGGGCGCCTTCACAGGCATCAGGCAGCCACTCCTACTTTCTCCAGCCTGAGCACACCTA CAGAGAGACAGTGTTGGGGGTGACAGGATGCCCCAGAAAAATTCAGGATACTTCTGAAATTGCCATGTTT GTCTCAGAACTTGTATCTTGCGTTTGGCCCTCAGCTTTAGCACTTTTTCCCACTTGCAGAGTCTTTCAGT TGTGCTTGGTAGCCAGGCTCAACACACCGGGGCTTTAGACTCAAGCAGCTTATATGGGAAGCTGGAGACC CCTGCCAGCCAGAGCACAGTAAGGGCTCGGAGAAGGTATGTGAACTAGGGTATCTGATGTGGTAGTGCAG TTGGTGTCTGGCATTGTGACGACAAGGGACTTGCCTCCCTTCTTGCCACTGAGGCCCTTGCTTTTCCTTC AGCTCTTGGCCTGTTGGTCCGGTTTATTAGTGAGAGCTAGTTTGCTCCAGGTGGTTAAAGGATGTAGCAG GAGGAATGGTGGAAGATGGGAGCTGCCCGGGTTAGTACAGAAGAGGTCTGTCTATCTGACCTAGCACTGA GGGGTTCACAAACCTGTGAGGTGCACCTCACTAATTTTGGCTCATCCCTGCCTTGCTACAAGCTCCCTGT GGCCACCATTCTCTGGACTGTACCGTGCTGATGACTGCAGCTGGCTACAAAACAGCATGAGAACCTGGCC GCTGTTCTCCTACTGCCTCCACCCTCAGGCAGGCCTCCTCCTCTTCTGCCCCTGAAGCCTCCTGCTGCTT GCTCCTCCTGCCTCCACCCTCAGGCAGGCCTCCTCCTCTTCTGCCCCTGAAGCCTCCTGCTGCTGCTCCT CCACCTCAGTCAGTGCTGAACTTCTCACTGTTGAGTGTTGAAATTGTTAATGGTCAAAGCAGGGAGGATG CCAGTCACCAAGGTTGATTGTCTTGGGAAAGCAGTTTTAGAGTGATGAATCCTTTGTAGGACAGGTAGAG AGTATCTTAGAGATAAAAAAATGGGCTATGTCCTCTCCTGCCCATGTCTTGTGCTCACTCGCCCCTCAGT CTACCCTTTTTGCTGGGACAGTGATGGTCTTGGCCAAGGTCAGCATGTAATGGAAAGACAGTGTATTGCC AGGCTGGATAGATGGGGTCATCTCACAGTGGGTCACGTGAAAATCAGTGTCACGTAGTCCCAGTGAATGT TGTGTTCTTTCTGGGGGGAGGGGGGAATAGAATAAACTCAAATTCTTTTTCAGTATAGCCCCTGAGTAAT GAATGAAAATTTGAGCTTATGTAAGTAAAGATTCATTTATGCCACCAGGGAGAGCCTGTATCTGAGAGAC ATTTAGCAGAGAGCACTTTAGTTTTTTGCTGCTAACTGTTGTGTGATCCTTTGCTGGGGTGCAAAAGGCA CCGGACACAGTGTGTTTGCTTCTGGTATATTTAGGTGATGCATCCGCCTGGGTTACCTGTATCTCTGCTG ATCATATTGGAAACTAAAATAAAGCCCCATTTGTGACCCTGAAAAAAAAAAAAAAAAA
Restriction Sites RsrII-NotI |
ACCN NM_133201
Insert Size 2274 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq BC046503, AAH46503
RefSeq Size 4258 bp
RefSeq ORF 2274 bp
Locus ID 170731
UniProt ID Q80U63
Cytogenetics 4 E1
Summary Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12527753, PubMed:23921378, PubMed:23620051). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (By similarity). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (PubMed:23921556). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (PubMed:23921556).UniProtKB/Swiss-Prot Function
Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1 through 7) encode the same protein.
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Documents
Resources
"NM_133201" in other vectors (4)
SKU Description Size Price
MG210494 Mfn2 (tGFP-tagged) - Mouse mitofusin 2 (Mfn2) 10 ug
$894.00
MR210494 Mfn2 (Myc-DDK-tagged) - Mouse mitofusin 2 (Mfn2), nuclear gene encoding mitochondrial protein 10 ug
$589.00 $694.00
MR210494L3 Lenti ORF clone of Mfn2 (Myc-DDK-tagged) - Mouse mitofusin 2 (Mfn2), nuclear gene encoding mitochondrial protein 10 ug
$994.00
MR210494L4 Lenti ORF clone of Mfn2 (mGFP-tagged) - Mouse mitofusin 2 (Mfn2), nuclear gene encoding mitochondrial protein 10 ug
$994.00

file-alt Citations

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