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Mfn2 (NM_133201) Mouse Tagged Lenti ORF Clone

  • LentiORF®
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SKU
MR210494L3
Lenti ORF clone of Mfn2 (Myc-DDK-tagged) - Mouse mitofusin 2 (Mfn2), nuclear gene encoding mitochondrial protein
Interest in protein/lysate? Submit request here!
ORF Plasmid:
DDK tGFP DDK
Lentiviral Particles:
DDK w/ Puro mGFP w/ Puro
AAV Particle:
DDK
  $994.00
In Stock*
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Specifications
Specifications
Product Data
Type Mouse Tagged ORF Clone
Target Symbol Mfn2
Synonyms D630023P19Rik; Fzo
Vector pLenti-C-Myc-DDK-P2A-Puro
E. coli Selection Chloramphenicol (34 ug/mL)
Mammalian Cell Selection Puromycin
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(MR210494).
Restriction Sites SgfI-MluI Cloning Scheme for this gene | Plasmid Map
ACCN NM_133201
ORF Size 2271 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_133201.2, NP_573464.2
RefSeq Size 4476 bp
RefSeq ORF 2274 bp
Locus ID 170731
UniProt ID Q80U63
Cytogenetics 4 E1
Summary Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12527753, PubMed:23921378, PubMed:23620051). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (By similarity). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (PubMed:23921556). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (PubMed:23921556).UniProtKB/Swiss-Prot Function
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"NM_133201" in other vectors (4)
SKU Description Size Price
MC205980 Mfn2 (untagged) - Mouse mitofusin 2 (Mfn2), nuclear gene encoding mitochondrial protein, (10ug) 10 ug
$694.00
MG210494 Mfn2 (tGFP-tagged) - Mouse mitofusin 2 (Mfn2) 10 ug
$894.00
MR210494 Mfn2 (Myc-DDK-tagged) - Mouse mitofusin 2 (Mfn2), nuclear gene encoding mitochondrial protein 10 ug
$589.00 $694.00
MR210494L4 Lenti ORF clone of Mfn2 (mGFP-tagged) - Mouse mitofusin 2 (Mfn2), nuclear gene encoding mitochondrial protein 10 ug
$994.00

Plasmid Map for MR210494L3

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Cloning scheme for MR210494L3
Circular map for MR210494L3

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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