E Cadherin (CDH1) Mouse Monoclonal Antibody [Clone ID: UMAB184]

SKU
UM870076
CDH1 mouse monoclonal antibody,clone UMAB184
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$224.00
In Stock*
Specifications
Product Data
Clone Name UMAB184
Application 10k-ChIP, FC, IF, IHC, WB
Recommended Dilution IHC 1:100~200
Reactivity Human
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen The extracellular domain of human CDH1 (NP_004351) produced in human cells.
Buffer PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 0.5~1.0 mg/ml (Lot Dependent)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 94.8 kDa
Gene Name cadherin 1
Database Link
Background This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]
Synonyms Arc-1; CD324; CDHE; ECAD; LCAM; UVO
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways Adherens junction, Bladder cancer, Cell adhesion molecules (CAMs), Endometrial cancer, Melanoma, Pathogenic Escherichia coli infection, Pathways in cancer, Thyroid cancer
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SKU Description Size Price
UM800076 CDH1 mouse monoclonal antibody,clone UMAB184 100 ul
$610.00
UM800076CF Carrier-free (BSA/glycerol-free) CDH1 mouse monoclonal antibody,clone UMAB184 100 ug
$657.00

Citations

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