SETBP1 (NM_015559) Human Tagged ORF Clone
- TrueORF®
SKU
RC229443
SETBP1 (Myc-DDK-tagged)-Human SET binding protein 1 (SETBP1), transcript variant 1
$589.00
$1,365.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | SETBP1 |
| Synonyms | MRD29; SEB |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_015559 |
| ORF Size | 4788 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_015559.3 |
| RefSeq ORF | 4791 bp |
| Locus ID | 26040 |
| UniProt ID | Q9Y6X0 |
| Cytogenetics | 18q12.3 |
| Domains | AT_hook |
| MW | 174.8 kDa |
| Summary | This gene encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication. Mutations in this gene are associated with Schinzel-Giedion midface retraction syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Aug 2011 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_015559" in other vectors (7)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC229443L1 | Lenti-ORF clone of SETBP1 (Myc-DDK-tagged)-Human SET binding protein 1 (SETBP1), transcript variant 1 | 10 ug |
$1,665.00
|
|
| RC229443L2 | Lenti-ORF clone of SETBP1 (mGFP-tagged)-Human SET binding protein 1 (SETBP1), transcript variant 1 | 10 ug |
$1,665.00
|
|
| RC229443L3 | Lenti-ORF clone of SETBP1 (Myc-DDK-tagged)-Human SET binding protein 1 (SETBP1), transcript variant 1 | 10 ug |
$1,665.00
|
|
| RC229443L4 | Lenti-ORF clone of SETBP1 (mGFP-tagged)-Human SET binding protein 1 (SETBP1), transcript variant 1 | 10 ug |
$1,665.00
|
|
| RG229443 | SETBP1 (tGFP-tagged) - Human SET binding protein 1 (SETBP1), transcript variant 1 | 10 ug |
$1,565.00
|
|
| SC114671 | SETBP1 (untagged)-Human SET binding protein 1 (SETBP1), transcript variant 1 | 10 ug |
$1,320.00
|
|
| SC328078 | SETBP1 (untagged)-Human SET binding protein 1 (SETBP1) transcript variant 1 | 10 ug |
$1,502.00
|
|
Citations
SETBP1 variants outside the degron disrupt DNA-binding, transcription and neuronal differentiation capacity to cause a heterogeneous neurodevelopmental disorder
Wong, Kampen, Braden et al
Nat Commun (2025) 16 (1), 9021 DOI: 10.1038/s41467-025-64074-x
Wong, Kampen, Braden et al
Nat Commun (2025) 16 (1), 9021 DOI: 10.1038/s41467-025-64074-x
Cited by 5
AI Summary: OriGene’s pCMV-Entry-SETBP1 (RC229443) plasmid was used as the template for generating SETBP1 variant constructs, enabling the study of how different SETBP1 mutations affect DNA-binding, transcription, and neuronal differentiation in this neurodevelopmental disorder research.
Snippet: upplementary Data 7. DNA constructs and site-directed mutagenesis The full-length SETBP1 construct fused to a C-terminal Myc-DDK tag under a human CMV promoter (pCMV-Entry-SETBP1) was purchased from Origene (RC229443). Constructs carrying SETBP1 variants (pCMV-Entry-SETBP1) were generated using QuikChange Lightning Site-Directed Mutagenesis Kit (Agilent) following the manufacturer’s protocol. T
Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies
Acuna-Hidalgo, Deriziotis, Steehouwer et al
PLoS Genet. (2017) 13 (3), e1006683 DOI: 10.1371/journal.pgen.1006683
Acuna-Hidalgo, Deriziotis, Steehouwer et al
PLoS Genet. (2017) 13 (3), e1006683 DOI: 10.1371/journal.pgen.1006683
Showing 1-2 of 2 papers.
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