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MCL1 (NM_021960) Human Tagged ORF Clone Lentiviral Particle

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RC200521L1V
Lenti ORF particles, MCL1 (Myc-DDK tagged) - Human myeloid cell leukemia sequence 1 (BCL2-related) (MCL1), nuclear gene encoding mitochondrial protein, transcript variant 1, 200ul, >10^7 TU/mL
  $1,236.00
2 Weeks*
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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Target Symbol MCL1
Synonyms bcl2-L-3; BCL2L3; EAT; Mcl-1; MCL1-ES; mcl1/EAT; MCL1L; MCL1S; TM
Vector pLenti-C-Myc-DDK
Mammalian Cell Selection None
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC200521).
ACCN NM_021960
ORF Size 1050 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_021960.3
RefSeq Size 4020 bp
RefSeq ORF 1053 bp
Locus ID 4170
UniProt ID Q07820
Cytogenetics 1q21.2
Domains Bcl-2
Protein Families Druggable Genome, Transmembrane
MW 37.2 kDa
Summary This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. provided by RefSeq, Oct 2010
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Documents
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file-alt Citations

Personalized targeting of BCL2 family proteins overcomes acquired resistance to BRAF-MEK inhibitors in preclinical melanoma
Y N, de Groot, Loftin et al
Nat Commun (2026)
Cited by 1
AI Summary: OriGene’s pLenti-C-Myc vector expressing human MCL1 (cat # RC200521L1V) was used to overexpress MCL1 in melanoma cells, enabling the study to functionally validate MCL1’s role in resistance to BRAF-MEK inhibitor therapies.
Snippet: There are currently no effective targeted therapies for BRAF-mutant metastatic melanoma patients with acquired resistance to approved BRAF and MEK inhibitors (BRAFi;- There are currently no effective targeted therapies for BRAF-mutant metastatic melanoma patients with acquired resistance to approved BRAF and MEK inhibitors (BRAFi;Cells were seeded in 6 well plates and infected with 107 CFU lentiviral particles expressing human MCL1 (NM_021960) in a pLenti-C-Myc vector (OriGene cat # RC200521L1V) or empty control in the same vector using standard lentiviral infection with 10 µg/ml polybrene
Showing 1-1 of 1 papers.
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