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SOD2 Human shRNA Plasmid Kit (Locus ID 6648)

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SKU
TR309190
SOD2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 6648
Synonyms GClnc1; IPO-B; IPOB; Mn-SOD; MNSOD; MVCD6
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components SOD2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 6648). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC016934, NM_000636, NM_001024465, NM_001024466, NM_001322814, NM_001322815, NM_001322816, NM_001322817, NM_001322819, NM_001322820, NM_000636.1, NM_000636.2, NM_000636.3, NM_001024465.1, NM_001024465.2, NM_001024466.1, NM_001024466.2, BC016934.1, BC012423, BC012423.1, BC001980, BC016015, BC035422, BC041951, BM724413, BM994509, NM_000636.4, NM_001024465.3, NM_001024466.3
UniProt ID P04179
Summary This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. provided by RefSeq, Apr 2016
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells
Roy, Pratheeshkumar, Son et al
Toxicol. Appl. Pharmacol. (2016) 307, 81-90 DOI: 10.1016/j.taap.2016.07.016
Cited by 34
AI Summary: OriGene products contributed to this study by providing Nrf2, SOD2, and catalase shRNAs, which were used to selectively silence these genes and investigate their roles in Cr(VI)-induced inflammatory responses.
Snippet: 2014). Nrf2, SOD2 and catalase shRNAs were purchased from Origene (Rockville, MD) (Son et al., 2014 and Son et al., 2015a). Transfections were performed using Lipofectamine 2000 (Invitrogen) according to the manufacturer's protocol. ... Cite SaveSaving
Showing 1-1 of 1 papers.
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