Senp2 Mouse shRNA Plasmid (Locus ID 75826)
SKU
TL517117
Senp2 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 75826 |
|---|---|
| Synonyms | 2310007L05Rik; 4930538C18Rik; AI646780; AW554757; mKIAA1331; Smt3ip2; SuPr-1 |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | Senp2 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 75826). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | BC031652, NM_029457, NR_027488, NM_001357424, NM_029457.1, NM_029457.2, NM_029457.3, BC040805, BC042514 |
| UniProt ID | Q91ZX6 |
| Summary | Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1 (By similarity). Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620). Isoform 3 activates transcription.UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Accumulation of histone variant H3.3 with age is associated with profound changes in the histone methylation landscape
Tvardovskiy, Schwämmle, Kempf et al
Nucleic Acids Res. (2017) 45 (16), 9272-9289 DOI: 10.1093/nar/gkx696
Tvardovskiy, Schwämmle, Kempf et al
Nucleic Acids Res. (2017) 45 (16), 9272-9289 DOI: 10.1093/nar/gkx696
AI Summary: OriGene contributed to this study by providing human hepatocarcinoma and matched normal liver tissue protein lysates, which were used to analyze H3.3 levels and histone methylation changes.
Snippet: Human tissue samples Protein lysates of human hepatocarcinoma tissues and matched normal liver tissues were purchased from Acris Antibodies GmbH and from Origene Inc
SUMOylation determines the voltage required to activate cardiac IKs channels
Xiong, Li, Dai et al
PNAS (2017)
Xiong, Li, Dai et al
PNAS (2017)
AI Summary: OriGene Technologies provided lentiviral particles expressing GFP and an shRNA targeting mouse SENP2 or a scrambled control, which were used to manipulate SUMOylation pathways in neonatal cardiac myocytes to study their effect on IKs channel activation.
Snippet: All 5 versions Cite SaveSaving...;Lentiviral particlesexpressingGFPandanshRNAtargetingmouseSENP2orascrambled control (OriGene Technologies) were applied to nCM for 12 h, where indicated
Showing 1-2 of 2 papers.
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