Stk36 Mouse shRNA Plasmid (Locus ID 269209)
Specifications
| Product Data | |
| Locus ID | 269209 |
|---|---|
| Synonyms | 1700112N14Rik; B930045J24; FU; Fused; mKIAA1278 |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | Stk36 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 269209). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | BC043103, BC058698, NM_175031, NM_175031.1, NM_175031.2, NM_175031.3, BC043103.1, BC049721, BC061470 |
| UniProt ID | Q69ZM6 |
| Summary | Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia.UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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