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Ackr3 Mouse shRNA Plasmid (Locus ID 12778)

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SKU
TL515747
Ackr3 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Specifications
Specifications
Product Data
Locus ID 12778
Synonyms AW541270; Cmkor1; CXC-R7; CXCR-7; Cxcr7; RDC-1; Rdc1
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Ackr3 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 12778). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC015254, NM_001271607, NM_007722, NM_007722.1, NM_007722.2, NM_007722.3, NM_007722.4, NM_001271607.1
UniProt ID P56485
Summary Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Modulation of CXC-motif chemokine receptor 7, but not 4, expression is related to migration of the human prostate cancer cell LNCaP: regulation by androgen and inflammatory stimuli
Yu, Pham, Yu et al
Inflamm. Res. (2019)
Cited by 16
AI Summary: OriGene's CXCR7 shRNA and Control shRNA constructs (pGFP-C-shlenti plasmid) were used to create stable CXCR7 knockdown in prostate cancer cells, enabling the study of CXCR7's role in cell migration.
Snippet: To create CXCR7 stable knock down, CXCR7 shRNA and scrambled sequence shRNA (Control shRNA) constructs in pGFP-C-shlenti plasmid under the control of a U6 promoter were purchased from Origene Technology Inc. (Rockville, MD)
Proinflammatory CXCL12-CXCR4/CXCR7 signaling axis drives Myc-induced prostate cancer in obese mice
Saha, Ahn, Blando et al
Cancer Res. (2017)
AI Summary: OriGene’s pGFP-C-shLenti vectors were used to knock down CXCR4 and CXCR7 in HMVP2 prostate cancer cells, enabling the study to demonstrate the role of these receptors in CXCL12-driven cancer cell migration, invasion, and signaling.
Snippet: Page 9. 9 Knockdown of CXCR4 and CXCR7 Knockdown of CXCR4 and CXCR7 in HMVP2 cells were performed with pGFP-C-shLenti vector from Origene according to the manufacturer's instructions. Mouse CXCR4 or CXCR7 ... All 2 versions Cite SaveSaving
Platelet-derived SDF-1 primes the pulmonary capillary vascular niche to drive lung alveolar regeneration
Rafii, Cao, Lis et al
Nat. Cell Biol. (2015) 17 (2), 123-36 DOI: 10.1038/ncb3096
Cited by 151
AI Summary: In this study, OriGene’s shRNA clones TL305345 (for human CXCR7) and TL515747 (for mouse Cxcr7) were used to specifically knock down CXCR7 expression in pulmonary capillary endothelial cells, enabling the authors to dissect the role of CXCR7 in platelet-driven lung alveolar regeneration.
Snippet: …Human ​CXCR4 was silenced by treatment with combined shRNA clones: TRCN0000004052, TRCN0000004053, TRCN0000004054 and TRCN0000004055 (Open Biosystems), and ​CXCR7 was knocked down with clone TL305345 (OriGene). ​Cxcr4 was knocked down in mouse PCECs by transduction with a combination of clones TRCN0000028678, TRCN0000028704 and TRCN0000028724. ​Cxcr7 was silenced in mouse PCECs with shRNA cloneTL515747 from Origene
Showing 1-3 of 3 papers.
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