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Nfe2l2 Mouse shRNA Plasmid (Locus ID 18024)

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SKU
TL515053
Nfe2l2 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 18024
Synonyms Nr; Nrf2
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Nfe2l2 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 18024). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC026943, NM_010902, NR_132727, NM_010902.1, NM_010902.2, NM_010902.3, NM_010902.4, BC003340, BC057948
UniProt ID Q60795
Summary This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. provided by RefSeq, Sep 2015
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Contribution of p62/SQSTM1 to PDGF-BB-induced myofibroblast-like phenotypic transition in vascular smooth muscle cells lacking Smpd1 gene
Zhang, Guan, Chen et al
Cell Death Dis (2018) 9 (12), 1145 DOI: 10.1038/s41419-018-1197-2
AI Summary: OriGene contributed to this study by providing Sqstm1-mouse shRNA lentiviral particles (TL515047V), which were used to silence the p62/SQSTM1 gene and assess its role in PDGF-BB-induced phenotypic changes in vascular smooth muscle cells.
Snippet: … CYTO-ID Autophagy Detection Kit 2.0 was obtained from Enzo Life Sciences (New York, NY, USA). Sqstm1-mouse shRNA lentiviral particles (TL515047V) were prepared by Origene (Rockville, MD, USA)
FigureFigureFigure
Role of KEAP1/NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance
Jeong, Hoang, Lovejoy et al
Cancer Discov (2016)
AI Summary: OriGene’s shNrf2 expression plasmids (TL515053) were used in this study to experimentally manipulate NRF2 expression, enabling the authors to investigate the role of KEAP1/NRF2 mutations in lung squamous cell carcinoma development and radiation resistance.
Snippet: shNrf2 expression plasmids were purchased from OriGene (TL515053)
Disruption of nuclear factor (erythroid-derived-2)-like 2 antioxidant signaling: a mechanism for impaired activation of stem cells and delayed regeneration of skeletal muscle
Shelar, Narasimhan, Shanmugam et al
FASEB J. (2016)
Cited by 44
AI Summary: OriGene products, specifically the Nrf2 shRNA plasmids (TR30021 and TL515053A), were used to knock down Nrf2 expression in C2C12 cells, enabling the study of how Nrf2 disruption impairs muscle stem cell activation and regeneration.
Snippet: C2C12 cells were cultured in PM and at 50% confluence;cells were transfected with either 5 mg of control or small hairpin (sh)RNA plasmids specific against Nrf2 (TR30021 and TL515053A;OriGene Technologies, Rockville, MD, USA) using Lipofectamine 3000 ... Cite SaveSaving
Showing 1-3 of 3 papers.
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