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Neil1 Mouse shRNA Plasmid (Locus ID 72774)

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SKU
TL504774
Neil1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Specifications
Specifications
Product Data
Locus ID 72774
Synonyms 2810450N13Rik; NEH1; Nei1
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Neil1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 72774). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC043297, NM_028347, NM_001357409, NR_151685, NM_028347.1, NM_028347.2, BC034873, NM_028347.3
UniProt ID Q8K4Q6
Summary Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Regulation of NEIL1 protein abundance by RAD9 is important for efficient base excision repair
Panigrahi, Hopkins, Lieberman
Nucleic Acids Res. (2015)
Cited by 16
AI Summary: OriGene contributed to this study by providing the mouse Neil1 ORF clone (#MC211355), which was used to investigate the role of NEIL1 in base excision repair regulated by RAD9.
Snippet: All cell lines were cultured at 37°C, 5% CO 2. Plasmid construction and generation of cell lines. Mouse Neil1 and human NEIL1 ORF clones were purchased from Origene (#MC211355) and Genecopoeia (#A3833), respectively. ... Cite SaveSaving
Showing 1-1 of 1 papers.
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