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Ranbp2 Mouse shRNA Plasmid (Locus ID 19386)

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SKU
TL501860
Ranbp2 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Specifications
Specifications
Product Data
Locus ID 19386
Synonyms A430087B05Rik; AI256741; NUP358
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Ranbp2 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 19386). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_011240, NM_011240.1, NM_011240.2, NM_011240.3, BC030915
UniProt ID Q9ERU9
Summary E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1 (By similarity). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Nucleoporin Nup358 Downregulation Tunes the Neuronal Excitability in Mouse Cortical Neurons
Martínez-Rojas, Pischedda, Romero-Maldonado et al
Life (Basel) (2023) 13 (9) DOI: 10.3390/life13091791
Cited by 3
Snippet: (shCTRL, Origene TR30021) and a pool of four mouse gene-specific Nup358 shRNA constructs (shNup358, Origene TL501860) in pGFP-C-shLenti Vector (Origene, Save Cached
Ankyrin-G induces nucleoporin RanBP2/Nup358 to associate with the axon initial segment of neurons
Khalaf, Roncador, Pischedda et al
J. Cell. Sci. (2019)
AI Summary: OriGene’s pGFP-C-shLenti Vector-based scrambled negative control shRNA (sh-CTRL) and mouse Nup358 shRNA constructs (sh-Nup358) were used in this study to achieve targeted knockdown of Nup358, enabling the investigation of its role and localization in neuronal axon initial segments.
Snippet: The plasmids used for the knockdown experiments were: scrambled negative control shRNA (sh-CTRL), and a pool of four mouse gene-specific Nup358 shRNA constructs (sh-Nup358) in pGFP-C-shLenti Vector (Origene). The sh-AnkG target sequence, AGT TCA GAG GAA GTG AGT TAC, was retrieved from the RNAi Consortium (TRC) mouse shRNA library and the oligonucleotides were designed according to the TRC guidelines. …
Showing 1-2 of 2 papers.
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