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Npc1 Mouse shRNA Plasmid (Locus ID 18145)

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SKU
TL501501
Npc1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 18145
Synonyms A430089E03Rik; C85354; D18Ertd139e; D18Ertd723e; lcsd; nmf164; spm
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components Npc1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 18145). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC052437, BC054539, NM_008720, NM_008720.1, NM_008720.2
UniProt ID O35604
Summary Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment (PubMed:21896731, PubMed:22048958, PubMed:27551080). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (By similarity). May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Increased exosome secretion in neurons aging in vitro by NPC1-mediated endosomal cholesterol buildup
Guix, Capitán, Casadomé-Perales et al
Life Sci Alliance (2021) 4 (8) DOI: 10.26508/lsa.202101055
Cited by 36
AI Summary: OriGene products contributed to this study by providing the NPC1 shRNA (OriGene, #TL502431) used to downregulate NPC1 expression and the NPC1 antibody (OriGene, #TA502431) used for protein detection, enabling the authors to investigate the role of NPC1 in endosomal cholesterol buildup and exosome secretion in aging neurons.
FigureFigureFigure
Showing 1-1 of 1 papers.
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