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p53 (TP53) Human shRNA Plasmid Kit (Locus ID 7157)

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SKU
TL320558
TP53 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Specifications
Specifications
Product Data
Locus ID 7157
Synonyms BCC7; BMFS5; LFS1; P53; TRP53
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components TP53 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 7157). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_000546, NM_001126112, NM_001126113, NM_001126114, NM_001126115, NM_001126116, NM_001126117, NM_001126118, NM_001276695, NM_001276696, NM_001276697, NM_001276698, NM_001276699, NM_001276760, NM_001276761, NM_000546.1, NM_000546.2, NM_000546.3, NM_000546.4, NM_000546.5, NM_001126116.1, NM_001126117.1, NM_001126115.1, NM_001126114.1, NM_001126114.2, NM_001126113.1, NM_001126113.2, NM_001126112.1, NM_001126112.2, NM_001276696.1, NM_001276695.1, NM_001126118.1, NM_001276760.1, NM_001276761.1, NM_001276698.1, NM_001276699.1, NM_001276697.1, BC003596, BC003596.1, NM_000546.6, NM_001276761.2, NM_001276699.2, NM_001276696.2, NM_001276698.2, NM_001276697.2, NM_001276695.2, NM_001276760.2
UniProt ID P04637
Summary This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). provided by RefSeq, Dec 2016
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Crizotinib Synergizes with Chemotherapy in Preclinical Models of Neuroblastoma
Krytska, Ryles, Sano et al
Clin. Cancer Res. (2015)
AI Summary: OriGene products (shRNA p53 constructs TL320558A, TL3200558C, and copGFP control TR30021) were used to generate p53 knockdown and control neuroblastoma cell lines, enabling the study of p53’s role in drug response and synergy in this preclinical neuroblastoma research.
Snippet: (SEM). 258 259 Page 13. 13 shRNA p53 Knockdown and functionality testing 260 NB-1643 and SH-SY5Y cells were stably transfected with retrovirus targeting p53 (Origene 261 TL320558A and TL3200558C) or copGFP control (Origene TR30021). Infected cells were ... Cite SaveSaving
Endothelial p53 Deletion Improves Angiogenesis and Prevents Cardiac Fibrosis and Heart Failure Induced by Pressure Overload in Mice
Gogiraju, Xu, Bochenek et al
J Am Heart Assoc (2015) 4 (2) DOI: 10.1161/JAHA.115.001770
AI Summary: OriGene's lentivirus-based TP53 human shRNA construct was used in this study to generate stable p53 knockdown endothelial cells, enabling the investigation of how endothelial p53 deletion affects angiogenesis and cardiac fibrosis under pressure overload conditions.
Snippet: Human p53 shRNA expression vectors or scrambled non‐effective shRNA cassette (in pGFP‐C‐shLenti plasmid) were obtained from Amsbio. A lentivirus‐based TP53 human shRNA (OriGene) construct was used to generate a stable p53 knockdown endothelial cell ... Cite SaveSaving
Showing 1-2 of 2 papers.
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