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TNFAIP3 Human shRNA Plasmid Kit (Locus ID 7128)

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SKU
TL320557
TNFAIP3 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Other products for "TNFAIP3 or NM_001270507"

Specifications
Specifications
Product Data
Locus ID 7128
Synonyms A20; AISBL; OTUD7C; TNFA1P2
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components TNFAIP3 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 7128). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001270507, NM_001270508, NM_006290, NM_006290.1, NM_006290.2, NM_006290.3, NM_001270507.1, NM_001270508.1, BC041790, BC064689, BC098379, BC113871, BC114480, NM_001270508.2, NM_001270507.2, NM_006290.4
UniProt ID P21580
Summary This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. provided by RefSeq, Jul 2012
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis
Zhang, Wang, Zhao et al
Nat. Med. (2017)
AI Summary: OriGene's p-FOXO1 antibody (no. TA323072) was used in this study to detect phosphorylated FOXO1, contributing to the analysis of signaling pathways involved in the regulation of ASK1 and the progression of nonalcoholic steatohepatitis.
Snippet: Antibodies against p-FOXO1 (no. TA323072) were obtained from OriGene (Rockville, MD, USA), and antibodies against ASK1 were obtained from GeneTex (no. GTX107921, Irvine, CA, USA) and Abcam (no. 45178, Cambridge, MA, USA). Antibodies against TNFAIP3 (no. sc-32797)
Showing 1-1 of 1 papers.
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