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ABCA1 Human shRNA Plasmid Kit (Locus ID 19)

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SKU
TL315036
ABCA1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Other products for "ABCA1 or NM_005502"

Specifications
Specifications
Product Data
Locus ID 19
Synonyms ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1; HPALP1; TGD
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components ABCA1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 19). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC034824, NM_005502, NM_005502.1, NM_005502.2, NM_005502.3, BC146856, NM_005502.4
UniProt ID O95477
Summary The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in both alleles of this gene cause Tangier disease and familial high-density lipoprotein (HDL) deficiency. provided by RefSeq, Sep 2019
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
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file-alt Citations

ABCA1/ABCB1 Ratio Determines Chemo- and Immune-Sensitivity in Human Osteosarcoma
Belisario, Akman, Godel et al
Cells (2020) 9 (3) DOI: 10.3390/cells9030647
Cited by 48
AI Summary: OriGene products, including the ABCA1 shRNA plasmid (TL315036V), scrambled shRNA plasmid (TR30021V), and ABCA1 expression vector (SC127939), were used to manipulate ABCA1 expression in osteosarcoma cells, enabling the study of its role in chemo- and immune-sensitivity.
Snippet: 105) were transfected with a non-targeting (scrambled) shRNA plasmid (TR30021V) or with a mix of 4 unique shRNAs targeting ABCA1 (TL315036V), with a non-coding (empty) pCMV6-XL4 vector or with a ABCA1-expression vector (SC127939) (all from Origene, Rockville
Monitoring the itinerary of lysosomal cholesterol in Niemann-Pick Type C1-deficient cells after cyclodextrin treatment
Feltes, Gale, Moores et al
J. Lipid Res. (2020)
AI Summary: OriGene's shRNA plasmids targeting ABCA1 and ABCG1 were used to generate stable knockdown cell lines, enabling the study of cholesterol trafficking pathways in Niemann-Pick Type C1-deficient cells.
Snippet: For stable knockdown of ABCA1, or ABCG1, shRNA plasmids were obtained from Origene and used to produce lentivirus in HEK 293T cells according to the TransIT -Lenti protocol using TransIT -Lenti transfection reagent and Mission Lentiviral Packaging Mix
Showing 1-2 of 2 papers.
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