Apolipoprotein E (APOE) Human shRNA Plasmid Kit (Locus ID 348)

SKU TL314721

APOE - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 348
• Synonyms: AD2; APO-E; ApoE4; LDLCQ5; LPG
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: APOE - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 348). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: NM_000041, NM_001302688, NM_001302689, NM_001302690, NM_001302691, NM_000041.1, NM_000041.2, NM_000041.3, NM_001302689.1, NM_001302690.1, NM_001302691.1, NM_001302688.1, BC003557, BC003557.1, BM042032, NM_001302688.2, NM_000041.4, NM_001302689.2, NM_001302691.2
• UniProt ID: P02649
• Summary: The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient