CEACAM6 Human shRNA Plasmid Kit (Locus ID 4680)
SKU
TL314003
CEACAM6 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 4680 |
|---|---|
| Synonyms | CD66c; CEAL; NCA |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | CEACAM6 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 4680). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | NM_002483, NM_002483.1, NM_002483.2, NM_002483.3, NM_002483.4, NM_002483.5, NM_002483.6, BC005008, BC005008.1 |
| UniProt ID | P40199 |
| Summary | This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. provided by RefSeq, Apr 2014 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Biological Functions and Identification of Novel Biomarker Expressed on the Surface of Breast Cancer-Derived Cancer Stem Cells via Proteomic Analysis
Koh, You, Jung et al
Mol. Cells (2020) 43 (4), 384-396 DOI: 10.14348/molcells.2020.2230
Koh, You, Jung et al
Mol. Cells (2020) 43 (4), 384-396 DOI: 10.14348/molcells.2020.2230
Cited by 23
AI Summary: In this study, OriGene’s shRNA-CD66c and shRNA-scrambled lentiviral GFP vectors were used to experimentally validate the role of CD66c as a novel surface biomarker on breast cancer stem cells by enabling targeted gene knockdown and functional analysis.
Snippet: A total of 1 × 105 BCSCs sorted by the isolation kit were transfected with shRNA-CD66c in lentiviral GFP vector (Origene, USA) or shRNA-scrambled (SC) in lentiviral GFP vector (Origene) using TransIT-X2 (Mirus Bio, USA), following the manufacturer’s instructions. The same plasmid without any insert, as well as a plasmid with a scrambled vector, was used as negative controls. GFP expressing BCSCs w...
Showing 1-1 of 1 papers.
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